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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Allergy+Clin+Immunol+Pract
2016 ; 4
(4
): 584-9
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Infectious Chronic Rhinosinusitis
#MMPMID27393772
Bose S
; Grammer LC
; Peters AT
J Allergy Clin Immunol Pract
2016[Jul]; 4
(4
): 584-9
PMID27393772
show ga
Chronic rhinosinusitis (CRS) is a persistent inflammatory disease that affects a
multitude of people worldwide. The pathogenesis of CRS involves many factors
including genetics, status of the sinonasal microbiome, infections, and
environmental influences. Comorbidities associated with CRS include asthma,
allergic rhinitis, bronchiectasis, and certain kinds of immunodeficiency. CRS can
be divided into different subtypes based on endotypes and phenotypes. Infectious
CRS is one such category. The etiology of infectious CRS is usually secondary to
chronic bacterial infection that commonly begins with a viral upper respiratory
tract infection. Humoral antibody deficiencies can underlie difficult-to-treat or
recurrent CRS. Infectious CRS can be treated with antimicrobials, topical or oral
corticosteroids, and nasal saline irrigations. Patients with CRS and humoral
immunodeficiency may require an aggressive treatment approach including
immunoglobulin replacement therapy. Despite advancements in the field of CRS,
targeted therapies and reliable biomarkers are still lacking.