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2016 ; 2016
(ä): 7351964
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Infection-Related Focal Segmental Glomerulosclerosis in Children
#MMPMID27294131
Dettmar AK
; Oh J
Biomed Res Int
2016[]; 2016
(ä): 7351964
PMID27294131
show ga
Focal segmental glomerulosclerosis (FSGS) is the most common cause of steroid
resistant nephrotic syndrome in children. It describes a unique histological
picture of glomerular damage resulting from several causes. In the majority of
patients the causing agent is still unknown, but in some cases viral association
is evident. In adults, the most established FSGS causing virus is the human
immune-deficiency virus, which is related to a collapsing variant of FSGS.
Nevertheless, other viruses are also suspected for causing a collapsing or
noncollapsing variant, for example, hepatitis B virus, parvovirus B19, and
Cytomegalovirus. Although the systemic infection mechanism is different for these
viruses, there are similarities in the pathomechanism for the induction of FSGS.
As the podocyte is the key structure in the pathogenesis of FSGS, a direct
infection of these cells or immediate damage through the virus or viral
components has to be considered. Although viral infections are a very rare cause
for FSGS in children, the treating pediatric nephrologist has to be aware of a
possible underlying infection, as this has a relevant impact on therapy and
prognosis.