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10.1093/infdis/jiw355 http://scihub22266oqcxt.onion/10.1093/infdis/jiw355 C5853473!5853473 !27496976     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27496976 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Infect+Dis 2017 ; 215 (5 ): 813-817 Nephropedia Template TP {{tp|p=27496976 |t=2017. Infection-Induced Vascular Permeability Aids Mycobacterial Growth |pdf=|usr=}}{{27496976 }} gab.com Text Infection-Induced Vascular Permeability Aids Mycobacterial Growth JO: J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=27496976 #FOAvip Pathogenic mycobacteria trigger formation of organized granulomas. As granulomas mature, they induce angiogenesis and vascular permeability. Here, in a striking parallel to tumor pro-angiogenic signaling, we identify angiopoietin-2 (ANG-2) induction as an important component of vascular dysfunction during mycobacterial infection. Mycobacterial infection in humans and zebrafish results in robust induction of ANG-2 expression from macrophages and stromal cells. Using a small-molecule inhibitor closely related to one currently in clinical trials, we link ANG-2/TIE2 signaling to vascular permeability during mycobacterial infection. Targeting granuloma-induced vascular permeability via vascular endothelial-protein tyrosine phosphatase inhibition limits mycobacterial growth, suggesting a new strategy for host-directed therapies against tuberculosis. Twit Text FOAVip Infection-Induced Vascular Permeability Aids Mycobacterial Growth ????J Infect Dis http://www.kidney.de/pget.php?&tw=1&pmid=27496976 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27496976 #FOAvip English Wikipedia <ref>{{Cite pmid|27496976 }}</ref> Infection-Induced Vascular Permeability Aids Mycobacterial Growth #MMPMID27496976 Oehlers SH ; Cronan MR ; Beerman RW ; Johnson MG ; Huang J ; Kontos CD ; Stout JE ; Tobin DM J Infect Dis 2017[Mar]; 215 (5 ): 813-817 PMID27496976 show ga Pathogenic mycobacteria trigger formation of organized granulomas. As granulomas mature, they induce angiogenesis and vascular permeability. Here, in a striking parallel to tumor pro-angiogenic signaling, we identify angiopoietin-2 (ANG-2) induction as an important component of vascular dysfunction during mycobacterial infection. Mycobacterial infection in humans and zebrafish results in robust induction of ANG-2 expression from macrophages and stromal cells. Using a small-molecule inhibitor closely related to one currently in clinical trials, we link ANG-2/TIE2 signaling to vascular permeability during mycobacterial infection. Targeting granuloma-induced vascular permeability via vascular endothelial-protein tyrosine phosphatase inhibition limits mycobacterial growth, suggesting a new strategy for host-directed therapies against tuberculosis. |*Capillary Permeability [MESH] |Angiopoietin-2/genetics/*metabolism [MESH] |Animals [MESH] |Animals, Genetically Modified [MESH] |Disease Models, Animal [MESH] |Gene Expression Regulation [MESH] |Granuloma/microbiology [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Larva [MESH] |Macrophages/drug effects/microbiology [MESH] |Mycobacterium Infections/*pathology [MESH] |Mycobacterium/drug effects/*growth & development [MESH] |Receptor, TIE-2/metabolism [MESH] |Signal Transduction [MESH] |Tuberculosis/microbiology [MESH]Infection-Induced Vascular Permeability Aids Mycobacterial Growth (epmc).pdf DeepDyve Pubget Overpricing