Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28491853
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28491853
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Nephropathol
2017 ; 6
(2
): 53-57
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Infection associated acute interstitial nephritis; a case report
#MMPMID28491853
Raina R
; Ale S
; Chaturvedi T
; Fraley L
; Novak R
; Tanphaichitr N
J Nephropathol
2017[Mar]; 6
(2
): 53-57
PMID28491853
show ga
BACKGROUND: Acute interstitial nephritis (AIN) is a clinico-pathological syndrome
associated with a variety of infections, drugs, and sometimes with unknown
causes. It is a common cause of acute kidney injury (AKI) and subsequent renal
impairment, which often times is under-diagnosed. Infection-associated AIN occurs
as a consequence of many systemic bacterial, viral, and parasitic infec-tions;
however, its incidence has decreased significantly after the advent of
antimicrobials. Infection-associated AIN presents with both oliguric or
non-oliguric renal insufficiency, without the classical clinical triad of AIN
(fever, rash, and arthralgia). In this scenario the renal function is usually
reversible after the infection is treated. In most cases, patients with acute
renal failure present with extra-renal manifestations typically detected in
underlying infections. Renal biopsy serves as the most definitive test for both
the diagnosis and prognosis of AIN. CASE PRESENTATION: In this paper, we will
address one such case of biopsy-proven AIN. In this case, the patient presented
with severe AKI induced by anaerobic streptococcus, leading to a periodontal
abscess, which was successfully treated with corticosteroids and requiring renal
replacement therapy (RRT). CONCLUSIONS: AIN should be considered in the
differential for unexplained AKI. Initial management should include conservative
therapy by withdrawing any suspected causative agent. Renal biopsy is needed for
confirmation in cases where kidney function fails to improve within 5-7 days on
conservative therapy. Risk of immunosuppression is very important to consider
when giving steroids in patients with infection induced AIN, and steroids may
have to be delayed until the active infection is completely controlled.
free
free
free
