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2016 ; 186
(5
): 1166-79
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Induction of Colonic M Cells during Intestinal Inflammation
#MMPMID26948422
Bennett KM
; Parnell EA
; Sanscartier C
; Parks S
; Chen G
; Nair MG
; Lo DD
Am J Pathol
2016[May]; 186
(5
): 1166-79
PMID26948422
show ga
Intestinal M (microfold) cells are specialized epithelial cells overlying
lymphoid tissues in the small intestine. Unlike common enterocytes, M cells lack
an organized apical brush border, and are able to transcytose microparticles
across the mucosal barrier to underlying antigen-presenting cells. We found that
in both the dextran sodium sulfate and Citrobacter rodentium models of colitis,
significantly increased numbers of Peyer's patch (PP) phenotype M cells were
induced at the peak of inflammation in colonic epithelium, often accompanied by
loosely organized lamina propria infiltrates. PP type M cells are thought to be
dependent on cytokines, including tumor necrosis factor (TNF)-? and receptor
activator of nuclear factor kappa-B ligand; these cytokines were also found to be
induced in the inflamed tissues. The induction of M cells was abrogated by
anti-TNF-? blockade, suggesting that anti-TNF-? therapies may have similar
effects in clinical settings, although the functional consequences are not clear.
Our results suggest that inflammatory cytokine-induced PP type M cells may be a
useful correlate of chronic intestinal inflammation.
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