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10.1534/g3.117.300327 http://scihub22266oqcxt.onion/10.1534/g3.117.300327 C5940154!5940154 !29519936     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29519936 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       G3+(Bethesda) 2018 ; 8 (5 ): 1627-1635 Nephropedia Template TP {{tp|p=29519936 |t=2018. Inducible Genome Editing with Conditional CRISPR/Cas9 Mice |pdf=|usr=}}{{29519936 }} gab.com Text Inducible Genome Editing with Conditional CRISPR/Cas9 Mice JO: G3 (Bethesda) http://www.kidney.de/pget.php?&tw=1&pmid=29519936 #FOAvip Genetically engineered mouse models (GEMMs) are powerful tools by which to probe gene function in vivo, obtain insight into disease etiology, and identify modifiers of drug response. Increased sophistication of GEMMs has led to the design of tissue-specific and inducible models in which genes of interest are expressed or ablated in defined tissues or cellular subtypes. Here we describe the generation of a transgenic mouse harboring a doxycycline-regulated Cas9 allele for inducible genome engineering. This model provides a flexible platform for genome engineering since editing is achieved by exogenous delivery of sgRNAs and should allow for the modeling of a range of biological and pathological processes. Twit Text FOAVip Inducible Genome Editing with Conditional CRISPR/Cas9 Mice ????G3 (Bethesda) http://www.kidney.de/pget.php?&tw=1&pmid=29519936 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29519936 #FOAvip English Wikipedia <ref>{{Cite pmid|29519936 }}</ref> Inducible Genome Editing with Conditional CRISPR/Cas9 Mice #MMPMID29519936 Katigbak A ; Robert F ; Paquet M ; Pelletier J G3 (Bethesda) 2018[May]; 8 (5 ): 1627-1635 PMID29519936 show ga Genetically engineered mouse models (GEMMs) are powerful tools by which to probe gene function in vivo, obtain insight into disease etiology, and identify modifiers of drug response. Increased sophistication of GEMMs has led to the design of tissue-specific and inducible models in which genes of interest are expressed or ablated in defined tissues or cellular subtypes. Here we describe the generation of a transgenic mouse harboring a doxycycline-regulated Cas9 allele for inducible genome engineering. This model provides a flexible platform for genome engineering since editing is achieved by exogenous delivery of sgRNAs and should allow for the modeling of a range of biological and pathological processes. |*Gene Editing [MESH] |*Genome [MESH] |Adoptive Transfer [MESH] |Animals [MESH] |CRISPR-Cas Systems/*genetics [MESH] |Doxycycline/pharmacology [MESH] |Gene Expression/drug effects [MESH] |Genetic Engineering [MESH] |Hematopoietic Stem Cells/drug effects/metabolism [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Models, Animal [MESH] |Mouse Embryonic Stem Cells/drug effects/metabolism [MESH] |Proto-Oncogene Proteins c-myc/metabolism [MESH]Inducible Genome Editing with Conditional CRISPR/Cas9 Mice (epmc).pdf DeepDyve Pubget Overpricing