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10.1016/j.it.2015.04.004 http://scihub22266oqcxt.onion/10.1016/j.it.2015.04.004 C4470270!4470270 !25979654     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25979654 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25979654 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Immunol 2015 ; 36 (6 ): 337-43 Nephropedia Template TP {{tp|p=25979654 |t=2015. Indoctrinating T cells to attack pathogens through homeschooling |pdf=|usr=}}{{25979654 }} gab.com Text Indoctrinating T cells to attack pathogens through homeschooling JO: Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25979654 #FOAvip Adaptive immunity is predicated on the ability of the T cell repertoire to have pre-existing specificity for the universe of potential pathogens. Recent findings suggest that T cell receptor (TCR)-self-major histocompatibility protein (pMHC) interactions limit autoimmune responses while enhancing T cell response to foreign antigens. We review these findings here, placing them in context of the current understanding of how TCR-self-pMHC interactions regulate T cell activation thresholds, and suggest that TCR-self-pMHC interactions increase the efficiency of the T cell repertoire by giving a competitive advantage to peptide cross-reactive T cells. We propose that self-reactivity and peptide cross-reactivity are controlled by particular CDR3 sequence motifs, which would allow thymic selection to contribute to solving the feat of broad pathogen specificity by exporting T cells that are pre-screened by positive and negative selection for the ability to be 'moderately' peptide cross-reactive. Twit Text FOAVip Indoctrinating T cells to attack pathogens through homeschooling ????Trends Immunol http://www.kidney.de/pget.php?&tw=1&pmid=25979654 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25979654 #FOAvip English Wikipedia <ref>{{Cite pmid|25979654 }}</ref> Indoctrinating T cells to attack pathogens through homeschooling #MMPMID25979654 Parello CS ; Huseby ES Trends Immunol 2015[Jun]; 36 (6 ): 337-43 PMID25979654 show ga Adaptive immunity is predicated on the ability of the T cell repertoire to have pre-existing specificity for the universe of potential pathogens. Recent findings suggest that T cell receptor (TCR)-self-major histocompatibility protein (pMHC) interactions limit autoimmune responses while enhancing T cell response to foreign antigens. We review these findings here, placing them in context of the current understanding of how TCR-self-pMHC interactions regulate T cell activation thresholds, and suggest that TCR-self-pMHC interactions increase the efficiency of the T cell repertoire by giving a competitive advantage to peptide cross-reactive T cells. We propose that self-reactivity and peptide cross-reactivity are controlled by particular CDR3 sequence motifs, which would allow thymic selection to contribute to solving the feat of broad pathogen specificity by exporting T cells that are pre-screened by positive and negative selection for the ability to be 'moderately' peptide cross-reactive. |Adaptive Immunity/*immunology [MESH] |Animals [MESH] |Antigen-Presenting Cells/*immunology [MESH] |Autoimmunity/immunology [MESH] |Humans [MESH] |Major Histocompatibility Complex/*immunology [MESH] |Models, Immunological [MESH] |Peptides/immunology [MESH] |Receptors, Antigen, T-Cell/*immunology [MESH]Indoctrinating T cells to attack pathogens through homeschooling (epmc).pdf DeepDyve Pubget Overpricing