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2017 ; 21
(4
): 594-599
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Indirect Calorimetry: From Bench to Bedside
#MMPMID28670546
Gupta RD
; Ramachandran R
; Venkatesan P
; Anoop S
; Joseph M
; Thomas N
Indian J Endocrinol Metab
2017[Jul]; 21
(4
): 594-599
PMID28670546
show ga
Accurate determination of energy expenditure (EE) is vitally important yet often
neglected in clinical practice. Indirect calorimetry (IC) provides one of the
most sensitive, accurate, and noninvasive measurements of EE in an individual.
Over the last couple of decades, this technique has been applied to clinical
circumstances such as acute illness and parenteral nutrition. Beyond assessing
the nutritional needs, it has also shed light on various aspects of nutrient
assimilation, thermogenesis, the energetics of physical exercise, and the
pathogenesis of obesity and diabetes. However, because of little or no experience
with IC provided during medical education, the benefits of IC are poorly
appreciated. Newer technology, cost-effectiveness, and a better understanding of
how to interpret measurements should lead to more frequent use of IC. This review
focuses on the physicochemical background of IC, the various indications for use,
techniques and instruments, potential pitfalls in measurement, and the recent
advances in technology that has adapted the technique to long-term studies in
humans.
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