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10.1172/JCI107735 http://scihub22266oqcxt.onion/10.1172/JCI107735 C301533!301533 !4276134     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\4276134 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Clin+Invest 1974 ; 54 (1 ): 138-46 Nephropedia Template TP {{tp|p=4276134 |t=1974. Increased adenosine triphosphatase in leukocytes of asthmatic children |pdf=|usr=}}{{4276134 }} gab.com Text Increased adenosine triphosphatase in leukocytes of asthmatic children JO: J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=4276134 #FOAvip Adenosine triphosphatase (ATPase) activities were compared in leukocytes of asthmatic and nonasthmatic children. Both Mg(2+)- and Ca(2+)-dependent ATPase activities were significantly elevated in two membrane fractions (59 to 66%) and in a superntant fraction (68 to 72%) prepared from sonicated leukocytes of asthmatic subjects. Intact cell surface or ecto ATPase was also elevated (67 to 76%) in asthmatic leukocytes. Alternate day glucocorticosteroid therapy was associated with leukocyte ATPase activities intermediate between those for asthmatics not receiving steroids and for nonasthmatic control subjects. Incubation of normal leukocytes with 10(-8) M hydrocortisone or leukocyte membranes with 10(-4)-10(-3) M hydrocortisone in vitro also resulted in decreased ATPase activities. The elevated leukocyte ATPase activities appear to relate to the adrenergic imbalance in asthma previously characterized by reduced beta adrenergic responsiveness of adenylate cyclase and suggest the possibility of more than one enzymatic abnormality intrinsic to the asthmatic condition. Twit Text FOAVip Increased adenosine triphosphatase in leukocytes of asthmatic children ????J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=4276134 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=4276134 #FOAvip English Wikipedia <ref>{{Cite pmid|4276134 }}</ref> Increased adenosine triphosphatase in leukocytes of asthmatic children #MMPMID4276134 Coffey RG ; Hadden JW ; Middleton E Jr J Clin Invest 1974[Jul]; 54 (1 ): 138-46 PMID4276134 show ga Adenosine triphosphatase (ATPase) activities were compared in leukocytes of asthmatic and nonasthmatic children. Both Mg(2+)- and Ca(2+)-dependent ATPase activities were significantly elevated in two membrane fractions (59 to 66%) and in a superntant fraction (68 to 72%) prepared from sonicated leukocytes of asthmatic subjects. Intact cell surface or ecto ATPase was also elevated (67 to 76%) in asthmatic leukocytes. Alternate day glucocorticosteroid therapy was associated with leukocyte ATPase activities intermediate between those for asthmatics not receiving steroids and for nonasthmatic control subjects. Incubation of normal leukocytes with 10(-8) M hydrocortisone or leukocyte membranes with 10(-4)-10(-3) M hydrocortisone in vitro also resulted in decreased ATPase activities. The elevated leukocyte ATPase activities appear to relate to the adrenergic imbalance in asthma previously characterized by reduced beta adrenergic responsiveness of adenylate cyclase and suggest the possibility of more than one enzymatic abnormality intrinsic to the asthmatic condition. |Adenosine Triphosphatases/*blood [MESH] |Adolescent [MESH] |Asthma/drug therapy/*enzymology/metabolism [MESH] |Calcium/metabolism [MESH] |Cell Membrane/enzymology/metabolism [MESH] |Child [MESH] |Female [MESH] |Glucocorticoids/administration & dosage/therapeutic use [MESH] |Humans [MESH] |Hydrocortisone/pharmacology [MESH] |Leukocytes/drug effects/*enzymology/metabolism [MESH] |Magnesium/metabolism [MESH] |Male [MESH]Increased adenosine triphosphatase in leukocytes of asthmatic children(epmc).pdf DeepDyve Pubget Overpricing