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2015 ; 8
(ä): 297-306
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IncobotulinumtoxinA in aesthetics: Russian multidisciplinary expert consensus
recommendations
#MMPMID26089695
Yutskovskaya Y
; Gubanova E
; Khrustaleva I
; Atamanov V
; Saybel A
; Parsagashvili E
; Dmitrieva I
; Sanchez E
; Lapatina N
; Korolkova T
; Saromytskaya A
; Goltsova E
; Satardinova E
Clin Cosmet Investig Dermatol
2015[]; 8
(ä): 297-306
PMID26089695
show ga
BACKGROUND: Although there are various international consensus recommendations on
the use of botulinum neurotoxin type A (BoNT/A) in facial aesthetics, there are
no global or Russian guidelines on the optimal dose of incobotulinumtoxinA, free
from complexing proteins, within specific aesthetic indications. This article
reports the outcomes of two expert consensus meetings, conducted to review and
analyze efficacy and tolerability data for incobotulinumtoxinA in various facial
aesthetic indications and to give expert consensus recommendations to ensure best
clinical practice among Russian clinicians. METHODS: Thirteen dermatology and/or
plastic surgery experts attended meetings held in Paris, France (November 2013),
and Moscow, Russia (March 2014). The expert group reviewed and analyzed the
existing evidence, consensus recommendations, and Russian experts' extensive
practical experience of incobotulinumtoxinA in aesthetics to reach consensus on
optimal doses, potential dose adjustments, and injection sites of
incobotulinumtoxinA for facial aesthetics. RESULTS: All experts developed
guidance on the optimal doses for incobotulinumtoxinA treatment of different
regions of the upper and lower face. The expert panel agreed that there are no
differences in the efficacy and duration of the effect between the four BoNT/As
that are commercially available for facial aesthetic indications in Russia and
that, when administered correctly, all BoNT/As can achieve optimal results.
Experts also agreed that nonresponse to BoNT/A can be caused by neutralizing
antibodies. CONCLUSION: On the basis of the scientific and clinical evidence
available for incobotulinumtoxinA, coupled with the extensive clinical experience
of the consensus group, experts recommended the optimal doses of
incobotulinumtoxinA effective for treatment of wrinkles of the upper and lower
face to achieve the expected aesthetic outcome. These first Russian guidelines on
the optimal use of incobotulinumtoxinA for augmentation of glabellar lines,
periorbital wrinkles, forehead lines, bunny lines, perioral wrinkles, depressor
anguli oris, mentalis, masseters and platysmal bands, and performing the
Nefertiti lift, are presented here.
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