Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26134527
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Curr+Hematol+Malig+Rep
2015 ; 10
(3
): 272-81
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Incidence and Burden of the Myelodysplastic Syndromes
#MMPMID26134527
Cogle CR
Curr Hematol Malig Rep
2015[Sep]; 10
(3
): 272-81
PMID26134527
show ga
Since 2001, cases of myelodysplastic syndromes (MDSs) have been tracked by cancer
registries. Examining registry data in the USA, the reported age-adjusted
incidence of MDS per 100,000 was 3.3 per year for 2001-2003 and 4.9 per year for
2007-2011, with increases likely a result of growing awareness of reporting
requirements. However, active case-finding methods repeatedly demonstrate that
population-based registries have underestimated the incidence of MDS due to
underreporting and underdiagnosis. Using keyword search strategies of electronic
pathology reports or other novel case capture methods, the true incidence of MDS
has been estimated between 5.3 and 13.1 per 100,000. Using Medicare billing
claims data, the incidence of MDS per 100,000 in patients aged ?65 years has been
estimated between 75 and 162. MDS prevalence is estimated to be 60,000 and
-170,000 in the USA and projected to grow. Epidemiologic data can help estimate
the burden of MDS and expose unmet clinical needs. For example, patients with MDS
receiving transfusions had significantly higher reported health care costs versus
those that did not (3-year mean of $88,824 vs $29,519). Epidemiologic data also
revealed that most MDS patients receiving transfusions do not receive active
therapies, despite strong evidence that hypomethylating agents and lenalidomide
significantly reduce transfusion burden. Other unmet needs identified by
epidemiologic studies include high need for treatment options after failing
first-line therapy and shared decision making by older MDS patients.