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10.1038/srep44038 http://scihub22266oqcxt.onion/10.1038/srep44038 C5339820!5339820 !28266605     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28266605 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 44038 Nephropedia Template TP {{tp|p=28266605 |t=2017. In vivo microsampling to capture the elusive exposome |pdf=|usr=}}{{28266605 }} gab.com Text In vivo microsampling to capture the elusive exposome JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28266605 #FOAvip Loss and/or degradation of small molecules during sampling, sample transportation and storage can adversely impact biological interpretation of metabolomics data. In this study, we performed in vivo sampling using solid-phase microextraction (SPME) in combination with non-targeted liquid chromatography and high-resolution tandem mass spectrometry (LC-MS/MS) to capture the fish tissue exposome using molecular networking analysis, and the results were contrasted with molecular differences obtained with ex vivo SPME sampling. Based on 494 MS/MS spectra comparisons, we demonstrated that in vivo SPME sampling provided better extraction and stabilization of highly reactive molecules, such as 1-oleoyl-sn-glycero-3-phosphocholine and 1-palmitoleoyl-glycero-3-phosphocholine, from fish tissue samples. This sampling approach, that minimizes sample handling and preparation, offers the opportunity to perform longitudinal monitoring of the exposome in biological systems and improve the reliability of exposure-measurement in exposome-wide association studies. Twit Text FOAVip In vivo microsampling to capture the elusive exposome ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28266605 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28266605 #FOAvip English Wikipedia <ref>{{Cite pmid|28266605 }}</ref> In vivo microsampling to capture the elusive exposome #MMPMID28266605 Bessonneau V ; Ings J ; McMaster M ; Smith R ; Bragg L ; Servos M ; Pawliszyn J Sci Rep 2017[Mar]; 7 (ä): 44038 PMID28266605 show ga Loss and/or degradation of small molecules during sampling, sample transportation and storage can adversely impact biological interpretation of metabolomics data. In this study, we performed in vivo sampling using solid-phase microextraction (SPME) in combination with non-targeted liquid chromatography and high-resolution tandem mass spectrometry (LC-MS/MS) to capture the fish tissue exposome using molecular networking analysis, and the results were contrasted with molecular differences obtained with ex vivo SPME sampling. Based on 494 MS/MS spectra comparisons, we demonstrated that in vivo SPME sampling provided better extraction and stabilization of highly reactive molecules, such as 1-oleoyl-sn-glycero-3-phosphocholine and 1-palmitoleoyl-glycero-3-phosphocholine, from fish tissue samples. This sampling approach, that minimizes sample handling and preparation, offers the opportunity to perform longitudinal monitoring of the exposome in biological systems and improve the reliability of exposure-measurement in exposome-wide association studies. |*Environmental Exposure [MESH] |Animals [MESH] |Chromatography, Liquid [MESH] |Cypriniformes/*metabolism [MESH] |Female [MESH] |Male [MESH] |Metabolomics/*instrumentation/*methods [MESH] |Solid Phase Microextraction [MESH]In vivo microsampling to capture the elusive exposome (epmc).pdf DeepDyve Pubget Overpricing