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2017 ; 14
(8
): 1018-1027
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In vitro circularization of RNA
#MMPMID27668458
Müller S
; Appel B
RNA Biol
2017[Aug]; 14
(8
): 1018-1027
PMID27668458
show ga
Over the past 2 decades, different types of circular RNAs have been discovered in
all kingdoms of life, and apparently, those circular species are more abundant
than previously thought. Apart from circRNAs in viroids and viruses, circular
transcripts have been discovered in rodents more than 20 y ago and recently have
been reported to be abundant in many organisms including humans. Their exact
function remains still unknown, although one may expect extensive functional
studies to follow the currently dominant research into identification and
discovery of circRNA by sophisticated sequencing techniques and bioinformatics.
Functional studies require models and as such methods for preparation of circRNA
in vitro. Here, we will review current protocols for RNA circularization and
discuss future prospects in the field.
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