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10.3390/ijms17050626 http://scihub22266oqcxt.onion/10.3390/ijms17050626 C4881452!4881452 !27128905     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27128905 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27128905 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2016 ; 17 (5 ): ä Nephropedia Template TP {{tp|p=27128905 |t=2016. In Vivo Delivery Systems for Therapeutic Genome Editing |pdf=|usr=}}{{27128905 }} gab.com Text In Vivo Delivery Systems for Therapeutic Genome Editing JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27128905 #FOAvip Therapeutic genome editing technology has been widely used as a powerful tool for directly correcting genetic mutations in target pathological tissues and cells to cure of diseases. The modification of specific genomic sequences can be achieved by utilizing programmable nucleases, such as Meganucleases, zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly-interspaced short palindromic repeat-associated nuclease Cas9 (CRISPR/Cas9). However, given the properties, such as large size, negative charge, low membrane penetrating ability, as well as weak tolerance for serum, and low endosomal escape, of these nucleases genome editing cannot be successfully applied unless in vivo delivery of related programmable nucleases into target organisms or cells is achieved. Here, we look back at delivery strategies having been used in the in vivo delivery of three main genome editing nucleases, followed by methodologies currently undergoing testing in clinical trials, and potential delivery strategies provided by analyzing characteristics of nucleases and commonly used vectors. Twit Text FOAVip In Vivo Delivery Systems for Therapeutic Genome Editing ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=27128905 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27128905 #FOAvip English Wikipedia <ref>{{Cite pmid|27128905 }}</ref> In Vivo Delivery Systems for Therapeutic Genome Editing #MMPMID27128905 Wang L ; Li F ; Dang L ; Liang C ; Wang C ; He B ; Liu J ; Li D ; Wu X ; Xu X ; Lu A ; Zhang G Int J Mol Sci 2016[Apr]; 17 (5 ): ä PMID27128905 show ga Therapeutic genome editing technology has been widely used as a powerful tool for directly correcting genetic mutations in target pathological tissues and cells to cure of diseases. The modification of specific genomic sequences can be achieved by utilizing programmable nucleases, such as Meganucleases, zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the clustered regularly-interspaced short palindromic repeat-associated nuclease Cas9 (CRISPR/Cas9). However, given the properties, such as large size, negative charge, low membrane penetrating ability, as well as weak tolerance for serum, and low endosomal escape, of these nucleases genome editing cannot be successfully applied unless in vivo delivery of related programmable nucleases into target organisms or cells is achieved. Here, we look back at delivery strategies having been used in the in vivo delivery of three main genome editing nucleases, followed by methodologies currently undergoing testing in clinical trials, and potential delivery strategies provided by analyzing characteristics of nucleases and commonly used vectors. |*Gene Editing [MESH] |Adenoviridae/genetics [MESH] |CRISPR-Cas Systems/genetics [MESH] |DNA Repair [MESH] |Genetic Vectors/genetics/metabolism [MESH] |Lentivirus/genetics [MESH] |Transcription Activator-Like Effector Nucleases/genetics [MESH]In Vivo Delivery Systems for Therapeutic Genome Editing (epmc).pdf DeepDyve Pubget Overpricing