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10.1097/SPC.0000000000000270 http://scihub22266oqcxt.onion/10.1097/SPC.0000000000000270 C5419813!5419813 !28375883     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28375883 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Support+Palliat+Care 2017 ; 11 (2 ): 112-117 Nephropedia Template TP {{tp|p=28375883 |t=2017. Improving the treatment of infant pain |pdf=|usr=}}{{28375883 }} gab.com Text Improving the treatment of infant pain JO: Curr Opin Support Palliat Care http://www.kidney.de/pget.php?&tw=1&pmid=28375883 #FOAvip PURPOSE OF REVIEW: Pain management presents a major challenge in neonatal care. Newborn infants who require medical treatment can undergo frequent invasive procedures during a critical period of neurodevelopment. However, adequate analgesic provision is infrequently and inconsistently provided for acute noxious procedures because of limited and conflicting evidence regarding analgesic efficacy and safety of most commonly used pharmacological agents. Here, we review recent advances in the measurement of infant pain and discuss clinical trials that assess the efficacy of pharmacological analgesia in infants. RECENT FINDINGS: Recently developed measures of noxious-evoked brain activity are sensitive to analgesic modulation, providing an objective quantitative outcome measure that can be used in clinical trials of analgesics. SUMMARY: Noxious stimulation evokes changes in activity across all levels of the infant nervous system, including reflex activity, altered brain activity and behaviour, and long-lasting changes in infant physiological stability. A multimodal approach is needed if we are to identify efficacious and well tolerated analgesic treatments. Well designed clinical trials are urgently required to improve analgesic provision in the infant population. Twit Text FOAVip Improving the treatment of infant pain ????Curr Opin Support Palliat Care http://www.kidney.de/pget.php?&tw=1&pmid=28375883 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28375883 #FOAvip English Wikipedia <ref>{{Cite pmid|28375883 }}</ref> Improving the treatment of infant pain #MMPMID28375883 Moultrie F ; Slater R ; Hartley C Curr Opin Support Palliat Care 2017[Jun]; 11 (2 ): 112-117 PMID28375883 show ga PURPOSE OF REVIEW: Pain management presents a major challenge in neonatal care. Newborn infants who require medical treatment can undergo frequent invasive procedures during a critical period of neurodevelopment. However, adequate analgesic provision is infrequently and inconsistently provided for acute noxious procedures because of limited and conflicting evidence regarding analgesic efficacy and safety of most commonly used pharmacological agents. Here, we review recent advances in the measurement of infant pain and discuss clinical trials that assess the efficacy of pharmacological analgesia in infants. RECENT FINDINGS: Recently developed measures of noxious-evoked brain activity are sensitive to analgesic modulation, providing an objective quantitative outcome measure that can be used in clinical trials of analgesics. SUMMARY: Noxious stimulation evokes changes in activity across all levels of the infant nervous system, including reflex activity, altered brain activity and behaviour, and long-lasting changes in infant physiological stability. A multimodal approach is needed if we are to identify efficacious and well tolerated analgesic treatments. Well designed clinical trials are urgently required to improve analgesic provision in the infant population. |Acetaminophen/therapeutic use [MESH] |Administration, Cutaneous [MESH] |Analgesics, Opioid/administration & dosage/adverse effects/pharmacology/*therapeutic use [MESH] |Anti-Inflammatory Agents, Non-Steroidal/therapeutic use [MESH] |Brain/*metabolism [MESH] |Humans [MESH] |Infant, Newborn [MESH] |Morphine/administration & dosage/adverse effects/pharmacology/*therapeutic use [MESH] |Pain Management/*methods [MESH] |Pain Measurement [MESH] |Pain/*drug therapy/physiopathology [MESH]Improving the treatment of infant pain (epmc).pdf DeepDyve Pubget Overpricing