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2017 ; 17
(5
): 1167-1175
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Implications of Resident Memory T Cells for Transplantation
#MMPMID27804207
Beura LK
; Rosato PC
; Masopust D
Am J Transplant
2017[May]; 17
(5
): 1167-1175
PMID27804207
show ga
Recent studies have established resident memory T cells (T(RM) ) as the dominant
memory lymphocyte population surveying most nonlymphoid tissues. Unlike other
memory T cell lineages, T(RM) do not recirculate through blood and are
permanently confined to their tissue of residence. T(RM) orchestrate local immune
responses and have been shown to accelerate local pathogen control in many
experimental infection models. Here we briefly summarize recent advances in T(RM)
differentiation, maintenance, and their protective function. While little is
known, we have speculated on the potential implications of T(RM) for
transplantation biology. Areas of emphasis include the role of passenger T(RM) in
controlling latent viral recrudescence in donor organs, donor T(RM) as a source
of graft-versus-host disease, the ability of T(RM) to potently induce
inflammation through sensing and alarm functions, and differentiation of host T
cells into T(RM) in response to local cues inside the allograft. Further
investigation of T(RM) in the context of transplantation might identify
therapeutic targets to prolong graft survival.
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