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2020 ; 40
(8
): 1193-1213
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Implications of COVID-19 in pediatric rheumatology
#MMPMID32500409
Batu ED
; Özen S
Rheumatol Int
2020[Aug]; 40
(8
): 1193-1213
PMID32500409
show ga
COVID-19 (coronavirus disease 2019) pandemic caused by SARS-CoV-2, is a global
public health issue threatening millions of lives worldwide. Although the
infection is mild in most of the affected individuals, it may cause severe
clinical manifestations such as acute respiratory distress syndrome or cytokine
storm leading to death. Children are affected less, and most experience a milder
disease. As rheumatologists, we deal with the uncontrolled response of the immune
system, and most of the drugs we use are either immune modulators or
immunosuppressants. Thus, the rheumatologists participate in the
multidisciplinary management of COVID-19 patients. On the other hand, our
patients with rheumatic diseases constitute a vulnerable group in this pandemic.
In this review, a systematic literature search was conducted utilizing
MEDLINE/PubMed and Scopus databases, and 231 COVID-19 patients with rheumatic
diseases have been identified. Only one of these patients was a child. Among
these, 9 (3.9%) died due to COVID-19. In light of the current data, the aspects
of COVID-19 resembling rheumatic diseases, the possible reasons for why children
are affected less severely, the hypothetic role of available vaccines in
preventing COVID-19, the unique position of patients with rheumatic diseases in
this pandemic, and the use of anti-rheumatic drugs in COVID-19 treatment are
discussed.
|*Betacoronavirus
[MESH]
|BCG Vaccine/immunology
[MESH]
|COVID-19
[MESH]
|Child
[MESH]
|Coronavirus Infections/*drug therapy/prevention & control
[MESH]
|Female
[MESH]
|Humans
[MESH]
|Male
[MESH]
|Measles-Mumps-Rubella Vaccine/immunology
[MESH]
|Pandemics/prevention & control
[MESH]
|Pneumonia, Viral/*drug therapy/prevention & control
[MESH]