Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3748/wjg.v23.i24.4330 http://scihub22266oqcxt.onion/10.3748/wjg.v23.i24.4330 C5487497!5487497 !28706416     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28706416 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28706416 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       World+J+Gastroenterol 2017 ; 23 (24 ): 4330-4340 Nephropedia Template TP {{tp|p=28706416 |t=2017. Implication of the Hedgehog pathway in hepatocellular carcinoma |pdf=|usr=}}{{28706416 }} gab.com Text Implication of the Hedgehog pathway in hepatocellular carcinoma JO: World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28706416 #FOAvip The prognosis for patients who are diagnosed with advanced stage hepatocellular carcinoma (HCC) is poor because there are few treatment options. Recent research has focused on the identification of novel molecular entities that can be targeted to inhibit oncogenic signals that are involved in the carcinogenesis, proliferation and progression of HCC. Among all of the pathways that are involved in the development of HCC, Hedgehog (HH) signalling has demonstrated a substantial role in hepatocarcinogenesis and HCC progression. HH plays a physiological role in embryogenesis, through the induction of the differentiation of hepatocytes from endodermal progenitors. The re-activation of the HH pathway in chronic damaged liver is a mechanism of fibrotic degeneration and is implicated in various stages of HCC development. HH activation sustains the sub-population of immature liver epithelial cells that are involved in the pathogenesis of cirrhosis and HCC, and HH itself is a mediator of the alcohol-derived malignant transformation of liver cells. High levels of expression of HH protein markers in liver tumour tissues are correlated with aggressive histological and biological features and a poor clinical outcome. In vitro and in vivo inhibition models of the HH pathway confirm that HH is essential in maintaining tumour growth, metastasis and a mesenchymal phenotype. Twit Text FOAVip Implication of the Hedgehog pathway in hepatocellular carcinoma ????World J Gastroenterol http://www.kidney.de/pget.php?&tw=1&pmid=28706416 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28706416 #FOAvip English Wikipedia <ref>{{Cite pmid|28706416 }}</ref> Implication of the Hedgehog pathway in hepatocellular carcinoma #MMPMID28706416 Della Corte CM ; Viscardi G ; Papaccio F ; Esposito G ; Martini G ; Ciardiello D ; Martinelli E ; Ciardiello F ; Morgillo F World J Gastroenterol 2017[Jun]; 23 (24 ): 4330-4340 PMID28706416 show ga The prognosis for patients who are diagnosed with advanced stage hepatocellular carcinoma (HCC) is poor because there are few treatment options. Recent research has focused on the identification of novel molecular entities that can be targeted to inhibit oncogenic signals that are involved in the carcinogenesis, proliferation and progression of HCC. Among all of the pathways that are involved in the development of HCC, Hedgehog (HH) signalling has demonstrated a substantial role in hepatocarcinogenesis and HCC progression. HH plays a physiological role in embryogenesis, through the induction of the differentiation of hepatocytes from endodermal progenitors. The re-activation of the HH pathway in chronic damaged liver is a mechanism of fibrotic degeneration and is implicated in various stages of HCC development. HH activation sustains the sub-population of immature liver epithelial cells that are involved in the pathogenesis of cirrhosis and HCC, and HH itself is a mediator of the alcohol-derived malignant transformation of liver cells. High levels of expression of HH protein markers in liver tumour tissues are correlated with aggressive histological and biological features and a poor clinical outcome. In vitro and in vivo inhibition models of the HH pathway confirm that HH is essential in maintaining tumour growth, metastasis and a mesenchymal phenotype. |*Signal Transduction [MESH] |Animals [MESH] |Antineoplastic Agents/therapeutic use [MESH] |Carcinogenesis/*pathology [MESH] |Carcinoma, Hepatocellular/drug therapy/*pathology [MESH] |Cell Differentiation [MESH] |Cell Transformation, Neoplastic/pathology [MESH] |Disease Models, Animal [MESH] |Disease Progression [MESH] |Hedgehog Proteins/genetics/*metabolism [MESH] |Hepatocytes/pathology [MESH] |Humans [MESH] |Liver Cirrhosis/pathology [MESH] |Liver Neoplasms/drug therapy/*pathology [MESH] |Liver/cytology/pathology [MESH] |MicroRNAs/metabolism [MESH]Implication of the Hedgehog pathway in hepatocellular carcinoma (epmc).pdf DeepDyve Pubget Overpricing