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Implication of sphingosin-1-phosphate in cardiovascular regulation
#MMPMID27100508
Li N
; Zhang F
Front Biosci (Landmark Ed)
2016[Jun]; 21
(7
): 1296-313
PMID27100508
show ga
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite generated by
phosphorylation of sphingosine catalyzed by sphingosine kinase. S1P acts mainly
through its high affinity G-protein-coupled receptors and participates in the
regulation of multiple systems, including cardiovascular system. It has been
shown that S1P signaling is involved in the regulation of cardiac chronotropy and
inotropy and contributes to cardioprotection as well as cardiac remodeling; S1P
signaling regulates vascular function, such as vascular tone and endothelial
barrier, and possesses an anti-atherosclerotic effect; S1P signaling is also
implicated in the regulation of blood pressure. Therefore, manipulation of S1P
signaling may offer novel therapeutic approaches to cardiovascular diseases. As
several S1P receptor modulators and sphingosine kinase inhibitors have been
approved or under clinical trials for the treatment of other diseases, it may
expedite the test and implementation of these S1P-based drugs in cardiovascular
diseases.
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