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2017 ; 2017
(ä): 9374563
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Implication of Ceramide Kinase in Adipogenesis
#MMPMID28951635
Ordoņez M
; Presa N
; Trueba M
; Gomez-Muņoz A
Mediators Inflamm
2017[]; 2017
(ä): 9374563
PMID28951635
show ga
Ceramide kinase (CerK) plays a critical role in the regulation of cell growth and
survival and has been implicated in proinflammatory responses. In this work, we
demonstrate that CerK regulates adipocyte differentiation, a process associated
with obesity, which causes chronic low-grade inflammation. CerK was upregulated
during differentiation of 3T3-L1 preadipocytes into mature adipocytes.
Noteworthy, knockdown of CerK using specific siRNA to silence the gene encoding
this kinase resulted in substantial decrease of lipid droplet formation and
potent depletion in the content of triacylglycerols in the adipocytes.
Additionally, CerK knockdown caused blockade of leptin secretion, an adipokine
that is crucial for regulation of energy balance in the organism and that is
increased in the obese state. Moreover, CerK gene silencing decreased the
expression of peroxisome proliferator-activated receptor gamma (PPAR?), which is
considered the master regulator of adipogenesis. It can be concluded that CerK is
a novel regulator of adipogenesis, an action that may have potential implications
in the development of obesity, and that targeting this kinase may be beneficial
for treatment of obesity-associated diseases.
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