Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28577591
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Behav+Ther
2017 ; 48
(4
): 567-580
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Implementing Clinical Research Using Factorial Designs: A Primer
#MMPMID28577591
Baker TB
; Smith SS
; Bolt DM
; Loh WY
; Mermelstein R
; Fiore MC
; Piper ME
; Collins LM
Behav Ther
2017[Jul]; 48
(4
): 567-580
PMID28577591
show ga
Factorial experiments have rarely been used in the development or evaluation of
clinical interventions. However, factorial designs offer advantages over
randomized controlled trial designs, the latter being much more frequently used
in such research. Factorial designs are highly efficient (permitting evaluation
of multiple intervention components with good statistical power) and present the
opportunity to detect interactions amongst intervention components. Such
advantages have led methodologists to advocate for the greater use of factorial
designs in research on clinical interventions (Collins, Dziak, & Li, 2009).
However, researchers considering the use of such designs in clinical research
face a series of choices that have consequential implications for the
interpretability and value of the experimental results. These choices include:
whether to use a factorial design, selection of the number and type of factors to
include, how to address the compatibility of the different factors included,
whether and how to avoid confounds between the type and number of interventions a
participant receives, and how to interpret interactions. The use of factorial
designs in clinical intervention research poses choices that differ from those
typically considered in randomized clinical trial designs. However, the great
information yield of the former encourages clinical researchers' increased and
careful execution of such designs.