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2012 ; 35
(5-6
): 363-74
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Impedance measurements in the biomedical sciences
#MMPMID22941962
Coffman FD
; Cohen S
Anal Cell Pathol (Amst)
2012[]; 35
(5-6
): 363-74
PMID22941962
show ga
Biological organisms and their component organs, tissues and cells have unique
electrical impedance properties. Impedance properties often change with changes
in structure, composition, and metabolism, and can be indicative of the onset and
progression of disease states. Over the past 100 years, instruments and
analytical methods have been developed to measure the impedance properties of
biological specimens and to utilize these measurements in both clinical and basic
science settings. This chapter will review the applications of impedance
measurements in the biomedical sciences, from whole body analysis to impedance
measurements of single cells and cell monolayers, and how cellular impedance
measuring instruments can now be used in high throughput screening applications.