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10.1155/2015/793292 http://scihub22266oqcxt.onion/10.1155/2015/793292 C4539175!4539175 !26339660     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26339660 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26339660 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Immunol+Res 2015 ; 2015 (ä): 793292 Nephropedia Template TP {{tp|p=26339660 |t=2015. Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis |pdf=|usr=}}{{26339660 }} gab.com Text Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis JO: J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26339660 #FOAvip The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated in vitro macrophages and dendritic cells, were investigated in the patients with pulmonary tuberculosis (TB) differing in lymphocyte reactivity to M. tuberculosis antigens (PPD-reactive versus PPD-anergic patients). We revealed the distinct impairments in patient APC functions. For example, the monocyte dysfunctions were displayed by low CD86 and HLA-DR expression, 2-fold increase in CD14(+)CD16(+) expression, the high numbers of IL-10-producing cells, and enhanced IL-10 and IL-6 production upon LPS-stimulation. The macrophages which were in vitro generated from peripheral blood monocytes under GM-CSF were characterized by Th1/Th2-balance shifting (downproduction of IFN-? coupled with upproduction of IL-10) and by reducing of allostimulatory activity in mixed lymphocyte culture. The dendritic cells (generated in vitro from peripheral blood monocytes upon GM-CSF + IFN-?) were characterized by impaired maturation/activation, a lower level of IFN-? production in conjunction with an enhanced capacity to produce IL-10 and IL-6, and a profound reduction of allostimulatory activity. The APC dysfunctions were found to be most prominent in PPD-anergic patients. The possible role of APC impairments in reducing the antigen-specific T-cell response to M. tuberculosis was discussed. Twit Text FOAVip Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis ????J Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=26339660 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26339660 #FOAvip English Wikipedia <ref>{{Cite pmid|26339660 }}</ref> Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis #MMPMID26339660 Sakhno LV ; Shevela EY ; Tikhonova MA ; Nikonov SD ; Ostanin AA ; Chernykh ER J Immunol Res 2015[]; 2015 (ä): 793292 PMID26339660 show ga The phenotype and functional properties of antigen-presenting cells (APC), that is, circulating monocytes and generated in vitro macrophages and dendritic cells, were investigated in the patients with pulmonary tuberculosis (TB) differing in lymphocyte reactivity to M. tuberculosis antigens (PPD-reactive versus PPD-anergic patients). We revealed the distinct impairments in patient APC functions. For example, the monocyte dysfunctions were displayed by low CD86 and HLA-DR expression, 2-fold increase in CD14(+)CD16(+) expression, the high numbers of IL-10-producing cells, and enhanced IL-10 and IL-6 production upon LPS-stimulation. The macrophages which were in vitro generated from peripheral blood monocytes under GM-CSF were characterized by Th1/Th2-balance shifting (downproduction of IFN-? coupled with upproduction of IL-10) and by reducing of allostimulatory activity in mixed lymphocyte culture. The dendritic cells (generated in vitro from peripheral blood monocytes upon GM-CSF + IFN-?) were characterized by impaired maturation/activation, a lower level of IFN-? production in conjunction with an enhanced capacity to produce IL-10 and IL-6, and a profound reduction of allostimulatory activity. The APC dysfunctions were found to be most prominent in PPD-anergic patients. The possible role of APC impairments in reducing the antigen-specific T-cell response to M. tuberculosis was discussed. |Adult [MESH] |Antigen-Presenting Cells/*immunology/metabolism [MESH] |Biomarkers [MESH] |Cytokines/metabolism [MESH] |Dendritic Cells/immunology/metabolism [MESH] |Female [MESH] |Humans [MESH] |Immunophenotyping [MESH] |Lymphocyte Activation/immunology [MESH] |Macrophages/immunology/metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Monocytes/immunology/metabolism [MESH] |Mycobacterium tuberculosis/*immunology/metabolism [MESH] |Phenotype [MESH] |T-Lymphocyte Subsets/immunology/metabolism [MESH] |Tuberculosis, Pulmonary/*immunology/metabolism [MESH]Impairments of Antigen-Presenting Cells in Pulmonary Tuberculosis (epmc).pdf DeepDyve Pubget Overpricing