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10.1080/15548627.2016.1207857 http://scihub22266oqcxt.onion/10.1080/15548627.2016.1207857 C5066937!5066937 !27463423     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27463423 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Autophagy 2016 ; 12 (10 ): 1876-1885 Nephropedia Template TP {{tp|p=27463423 |t=2016. Impaired autophagy in macrophages promotes inflammatory eye disease |pdf=|usr=}}{{27463423 }} gab.com Text Impaired autophagy in macrophages promotes inflammatory eye disease JO: Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=27463423 #FOAvip Autophagy is critical for maintaining cellular homeostasis. Organs such as the eye and brain are immunologically privileged. Here, we demonstrate that autophagy is essential for maintaining ocular immune privilege. Deletion of multiple autophagy genes in macrophages leads to an inflammation-mediated eye disease called uveitis that can cause blindness. Loss of autophagy activates inflammasome-mediated IL1B secretion that increases disease severity. Inhibition of caspase activity by gene deletion or pharmacological means completely reverses the disease phenotype. Of interest, experimental uveitis was also increased in a model of Crohn disease, a systemic autoimmune disease in which patients often develop uveitis, offering a potential mechanistic link between macrophage autophagy and systemic disease. These findings directly implicate the homeostatic process of autophagy in blinding eye disease and identify novel pathways for therapeutic intervention in uveitis. Twit Text FOAVip Impaired autophagy in macrophages promotes inflammatory eye disease ????Autophagy http://www.kidney.de/pget.php?&tw=1&pmid=27463423 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27463423 #FOAvip English Wikipedia <ref>{{Cite pmid|27463423 }}</ref> Impaired autophagy in macrophages promotes inflammatory eye disease #MMPMID27463423 Santeford A ; Wiley LA ; Park S ; Bamba S ; Nakamura R ; Gdoura A ; Ferguson TA ; Rao PK ; Guan JL ; Saitoh T ; Akira S ; Xavier R ; Virgin HW 4th ; Apte RS Autophagy 2016[Oct]; 12 (10 ): 1876-1885 PMID27463423 show ga Autophagy is critical for maintaining cellular homeostasis. Organs such as the eye and brain are immunologically privileged. Here, we demonstrate that autophagy is essential for maintaining ocular immune privilege. Deletion of multiple autophagy genes in macrophages leads to an inflammation-mediated eye disease called uveitis that can cause blindness. Loss of autophagy activates inflammasome-mediated IL1B secretion that increases disease severity. Inhibition of caspase activity by gene deletion or pharmacological means completely reverses the disease phenotype. Of interest, experimental uveitis was also increased in a model of Crohn disease, a systemic autoimmune disease in which patients often develop uveitis, offering a potential mechanistic link between macrophage autophagy and systemic disease. These findings directly implicate the homeostatic process of autophagy in blinding eye disease and identify novel pathways for therapeutic intervention in uveitis. |*Autophagy/genetics [MESH] |Animals [MESH] |Autophagy-Related Protein 5/metabolism [MESH] |Autophagy-Related Proteins/genetics [MESH] |Cytokines/genetics/metabolism [MESH] |Eye Diseases/*pathology [MESH] |Gene Deletion [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Inflammasomes/metabolism [MESH] |Inflammation/genetics/*pathology [MESH] |Interleukin-1beta/metabolism [MESH] |Macrophages/*pathology/ultrastructure [MESH] |Mice, Knockout [MESH] |Polymorphism, Single Nucleotide/genetics [MESH]Impaired autophagy in macrophages promotes inflammatory eye disease (epmc).pdf DeepDyve Pubget Overpricing