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10.1073/pnas.1415020112 http://scihub22266oqcxt.onion/10.1073/pnas.1415020112 C4313816!4313816 !25583514     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25583514 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2015 ; 112 (4 ): 1065-70 Nephropedia Template TP {{tp|p=25583514 |t=2015. Impaired Hippo signaling promotes Rho1-JNK-dependent growth |pdf=|usr=}}{{25583514 }} gab.com Text Impaired Hippo signaling promotes Rho1-JNK-dependent growth JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25583514 #FOAvip The Hippo and c-Jun N-terminal kinase (JNK) pathway both regulate growth and contribute to tumorigenesis when dysregulated. Whereas the Hippo pathway acts via the transcription coactivator Yki/YAP to regulate target gene expression, JNK signaling, triggered by various modulators including Rho GTPases, activates the transcription factors Jun and Fos. Here, we show that impaired Hippo signaling induces JNK activation through Rho1. Blocking Rho1-JNK signaling suppresses Yki-induced overgrowth in the wing disk, whereas ectopic Rho1 expression promotes tissue growth when apoptosis is prohibited. Furthermore, Yki directly regulates Rho1 transcription via the transcription factor Sd. Thus, our results have identified a novel molecular link between the Hippo and JNK pathways and implicated the essential role of the JNK pathway in Hippo signaling-related tumorigenesis. Twit Text FOAVip Impaired Hippo signaling promotes Rho1-JNK-dependent growth ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=25583514 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25583514 #FOAvip English Wikipedia <ref>{{Cite pmid|25583514 }}</ref> Impaired Hippo signaling promotes Rho1-JNK-dependent growth #MMPMID25583514 Ma X ; Chen Y ; Xu W ; Wu N ; Li M ; Cao Y ; Wu S ; Li Q ; Xue L Proc Natl Acad Sci U S A 2015[Jan]; 112 (4 ): 1065-70 PMID25583514 show ga The Hippo and c-Jun N-terminal kinase (JNK) pathway both regulate growth and contribute to tumorigenesis when dysregulated. Whereas the Hippo pathway acts via the transcription coactivator Yki/YAP to regulate target gene expression, JNK signaling, triggered by various modulators including Rho GTPases, activates the transcription factors Jun and Fos. Here, we show that impaired Hippo signaling induces JNK activation through Rho1. Blocking Rho1-JNK signaling suppresses Yki-induced overgrowth in the wing disk, whereas ectopic Rho1 expression promotes tissue growth when apoptosis is prohibited. Furthermore, Yki directly regulates Rho1 transcription via the transcription factor Sd. Thus, our results have identified a novel molecular link between the Hippo and JNK pathways and implicated the essential role of the JNK pathway in Hippo signaling-related tumorigenesis. |Animals [MESH] |Drosophila Proteins/genetics/*metabolism [MESH] |Drosophila melanogaster [MESH] |Imaginal Discs/cytology/*embryology [MESH] |Intracellular Signaling Peptides and Proteins/genetics/*metabolism [MESH] |JNK Mitogen-Activated Protein Kinases/genetics/*metabolism [MESH] |MAP Kinase Signaling System/*physiology [MESH] |Nuclear Proteins/genetics/metabolism [MESH] |Protein Serine-Threonine Kinases/genetics/*metabolism [MESH] |Trans-Activators/genetics/metabolism [MESH] |Transcription, Genetic/physiology [MESH] |Wings, Animal/cytology/*embryology [MESH] |YAP-Signaling Proteins [MESH]Impaired Hippo signaling promotes Rho1-JNK-dependent growth (epmc).pdf DeepDyve Pubget Overpricing