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2015 ; 13
(ä): 181
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Impact of heparanase on renal fibrosis
#MMPMID26040666
Masola V
; Zaza G
; Onisto M
; Lupo A
; Gambaro G
J Transl Med
2015[Jun]; 13
(ä): 181
PMID26040666
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Tubulo-interstitial fibrosis has been recognized as the hallmark of progression
of chronic kidney disease, but, despite intensive research studies, there are
currently no biomarkers or effective treatments for this condition. In this
context, a promising candidate could be heparanase-1 (HPSE), an endoglycosidase
that cleaves heparan sulfate chains and thus takes part in extracellular matrix
remodeling. As largely described, it has a central role in the pathogenesis of
cancer and inflammation, and it participates in the complex biological machinery
involved in the onset of different renal proteinuric diseases (e.g., diabetic
nephropathy, glomerulonephritis). Additionally, HPSE may significantly influence
the progression of chronic kidney damage trough its major role in the biological
pathway of renal fibrogenesis. Here, we briefly summarize data supporting the
role of HPSE in renal damage, focusing on recent evidences that demonstrate the
capability of this enzyme to modulate the signaling of pro-fibrotic factors such
as FGF-2 and TGF-? and consequently to control the epithelial-mesenchymal
transition in renal tubular cells. We also emphasize the need of the research
community to undertake studies and clinical trials to assess the potential
clinical employment of this enzyme as diagnostic and prognostic tool and/or its
role as therapeutic target for new pharmacological interventions.
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