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2014 ; 1
(3
): e963452
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Impact of acetylation on tumor metabolism
#MMPMID27308346
Zhao D
; Li FL
; Cheng ZL
; Lei QY
Mol Cell Oncol
2014[Jul]; 1
(3
): e963452
PMID27308346
show ga
Acetylation of protein lysine residues is a reversible and dynamic process that
is controlled by histone acetyltransferases (HATs) and deacetylases (HDACs and
SIRTs). Recent studies have revealed that acetylation modulates not only nuclear
proteins but also cytoplasmic or mitochondrial proteins, including many metabolic
enzymes. In tumors, cellular metabolism is reprogrammed to provide intermediates
for biosynthesis such as nucleotides, fatty acids, and amino acids, and thereby
favor the rapid proliferation of cancer cells and tumor development. An
increasing number of investigations have indicated that acetylation plays an
important role in tumor metabolism. Here, we summarize the substrates that are
modified by acetylation, especially oncogenes, tumor suppressor genes, and
enzymes that are implicated in tumor metabolism.
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