Immunosuppression in kidney transplantation
#MMPMID26527942
Muntean A
; Lucan M
Clujul Med
2013[]; 86
(3
): 177-80
PMID26527942
show ga
For most patients with chronic kidney failure, kidney transplantation has the
greatest potential for restoring a healthy and productive life. The risk of acute
rejection is the highest in the first months after transplantation (induction
phase) and diminishes afterwards (maintenance phase). Immunosuppression should be
at the highest level in the early period and reduced for long-term therapy. At
present, conventional immunosuppressive protocols consist of the triple therapy:
a calcineurin inhibitor, an adjunctive agent, corticosteroids. The development of
new immunosuppressives drugs is aimed not only at improving short-term outcomes,
but also achieving better safety, less nephrotoxicity and minimal side effects.
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