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10.1016/j.alit.2014.12.006 http://scihub22266oqcxt.onion/10.1016/j.alit.2014.12.006 C4675657!4675657 !25838086     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25838086 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Allergol+Int 2015 ; 64 (2 ): 121-30 Nephropedia Template TP {{tp|p=25838086 |t=2015. Immunopathology of chronic rhinosinusitis |pdf=|usr=}}{{25838086 }} gab.com Text Immunopathology of chronic rhinosinusitis JO: Allergol Int http://www.kidney.de/pget.php?&tw=1&pmid=25838086 #FOAvip Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses which persists for at least 12 weeks. CRS can be divided into two phenotypes dependent on the presence of nasal polyps (NPs); CRS with NPs (CRSwNP) and CRS without NPs (CRSsNP). Immunological patterns in the two diseases are known to be different. Inflammation in CRSsNP is rarely investigated and limited studies show that CRSsNP is characterized by type 1 inflammation. Inflammation in CRSwNP is well investigated and CRSwNP in Western countries shows type 2 inflammation and eosinophilia in NPs. In contrast, mixed inflammatory patterns are found in CRSwNP in Asia and the ratio of eosinophilic NPs and non-eosinophilic NPs is almost 50:50 in these countries. Inflammation in eosinophilic NPs is mainly controlled by type 2 cytokines, IL-5 and IL-13, which can be produced from several immune cells including Th2 cells, mast cells and group 2 innate lymphoid cells (ILC2s) that are all elevated in eosinophilic NPs. IL-5 strongly induces eosinophilia. IL-13 activates macrophages, B cells and epithelial cells to induce recruitment of eosinophils and Th2 cells, IgE mediated reactions and remodeling. Epithelial derived cytokines, TSLP, IL-33 and IL-1 can directly and indirectly control type 2 cytokine production from these cells in eosinophilic NPs. Recent clinical trials showed the beneficial effect on eosinophilic NPs and/or asthma by monoclonal antibodies against IL-5, IL-4R?, IgE and TSLP suggesting that they can be therapeutic targets for eosinophilic CRSwNP. Twit Text FOAVip Immunopathology of chronic rhinosinusitis ????Allergol Int http://www.kidney.de/pget.php?&tw=1&pmid=25838086 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25838086 #FOAvip English Wikipedia <ref>{{Cite pmid|25838086 }}</ref> Immunopathology of chronic rhinosinusitis #MMPMID25838086 Kato A Allergol Int 2015[Apr]; 64 (2 ): 121-30 PMID25838086 show ga Chronic rhinosinusitis (CRS) is a heterogeneous disease characterized by local inflammation of the upper airways and sinuses which persists for at least 12 weeks. CRS can be divided into two phenotypes dependent on the presence of nasal polyps (NPs); CRS with NPs (CRSwNP) and CRS without NPs (CRSsNP). Immunological patterns in the two diseases are known to be different. Inflammation in CRSsNP is rarely investigated and limited studies show that CRSsNP is characterized by type 1 inflammation. Inflammation in CRSwNP is well investigated and CRSwNP in Western countries shows type 2 inflammation and eosinophilia in NPs. In contrast, mixed inflammatory patterns are found in CRSwNP in Asia and the ratio of eosinophilic NPs and non-eosinophilic NPs is almost 50:50 in these countries. Inflammation in eosinophilic NPs is mainly controlled by type 2 cytokines, IL-5 and IL-13, which can be produced from several immune cells including Th2 cells, mast cells and group 2 innate lymphoid cells (ILC2s) that are all elevated in eosinophilic NPs. IL-5 strongly induces eosinophilia. IL-13 activates macrophages, B cells and epithelial cells to induce recruitment of eosinophils and Th2 cells, IgE mediated reactions and remodeling. Epithelial derived cytokines, TSLP, IL-33 and IL-1 can directly and indirectly control type 2 cytokine production from these cells in eosinophilic NPs. Recent clinical trials showed the beneficial effect on eosinophilic NPs and/or asthma by monoclonal antibodies against IL-5, IL-4R?, IgE and TSLP suggesting that they can be therapeutic targets for eosinophilic CRSwNP. |B-Lymphocytes/immunology [MESH] |Chronic Disease [MESH] |Cytokines/immunology [MESH] |Dendritic Cells/immunology [MESH] |Eosinophilia/immunology [MESH] |Humans [MESH] |Mast Cells/immunology [MESH] |Nasal Polyps/immunology [MESH] |Rhinitis/*immunology [MESH] |Sinusitis/*immunology [MESH]Immunopathology of chronic rhinosinusitis (epmc).pdf DeepDyve Pubget Overpricing