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2015 ; 107
(3
): 61-77
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Immunomodulatory role of microRNAs transferred by extracellular vesicles
#MMPMID25564937
Fernández-Messina L
; Gutiérrez-Vázquez C
; Rivas-García E
; Sánchez-Madrid F
; de la Fuente H
Biol Cell
2015[Mar]; 107
(3
): 61-77
PMID25564937
show ga
The immune system is composed of different cell types localised throughout the
organism to sense and respond to pathological situations while maintaining
homeostasis under physiological conditions. Intercellular communication between
immune cells is essential to coordinate an effective immune response and involves
both cell contact dependent and independent processes that ensure the transfer of
information between bystander and distant cells. There is a rapidly growing body
of evidence on the pivotal role of extracellular vesicles (EVs) in cell
communication and these structures are emerging as important mediators for immune
modulation upon delivery of their molecular cargo. In the last decade, EVs have
been shown to be efficient carriers of genetic information, including microRNAs
(miRNAs), that can be transferred between cells and regulate gene expression and
function on the recipient cell. Here, we review the current knowledge of
intercellular functional transfer of EV-delivered miRNAs and their putative role
in immune regulation.
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