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10.1101/cshperspect.a015578 http://scihub22266oqcxt.onion/10.1101/cshperspect.a015578 C3968789!3968789 !24616201     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24616201 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24616201 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cold+Spring+Harb+Perspect+Med 2014 ; 4 (4 ): a015578 Nephropedia Template TP {{tp|p=24616201 |t=2014. Immunological challenges and therapies in xenotransplantation |pdf=|usr=}}{{24616201 }} gab.com Text Immunological challenges and therapies in xenotransplantation JO: Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=24616201 #FOAvip Xenotransplantation, or the transplantation of cells, tissues, or organs between different species, was proposed a long time ago as a possible solution to the worldwide shortage of human organs and tissues for transplantation. In this setting, the pig is currently seen as the most likely candidate species. In the last decade, progress in this field has been remarkable and includes a better insight into the immunological mechanisms underlying the rejection process. Several immunological hurdles nonetheless remain, such as the strong antibody-mediated and innate or adaptive cellular immune responses linked to coagulation derangements, precluding indefinite xenograft survival. This article reviews our current understanding of the immunological mechanisms involved in xenograft rejection and the potential strategies that may enable xenotransplantation to become a clinical reality in the not-too-distant future. Twit Text FOAVip Immunological challenges and therapies in xenotransplantation ????Cold Spring Harb Perspect Med http://www.kidney.de/pget.php?&tw=1&pmid=24616201 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24616201 #FOAvip English Wikipedia <ref>{{Cite pmid|24616201 }}</ref> Immunological challenges and therapies in xenotransplantation #MMPMID24616201 Vadori M ; Cozzi E Cold Spring Harb Perspect Med 2014[Apr]; 4 (4 ): a015578 PMID24616201 show ga Xenotransplantation, or the transplantation of cells, tissues, or organs between different species, was proposed a long time ago as a possible solution to the worldwide shortage of human organs and tissues for transplantation. In this setting, the pig is currently seen as the most likely candidate species. In the last decade, progress in this field has been remarkable and includes a better insight into the immunological mechanisms underlying the rejection process. Several immunological hurdles nonetheless remain, such as the strong antibody-mediated and innate or adaptive cellular immune responses linked to coagulation derangements, precluding indefinite xenograft survival. This article reviews our current understanding of the immunological mechanisms involved in xenograft rejection and the potential strategies that may enable xenotransplantation to become a clinical reality in the not-too-distant future. |*Transplantation, Heterologous [MESH] |Animals [MESH] |Graft Rejection/*immunology/prevention & control [MESH] |Heart Transplantation/*methods [MESH] |Humans [MESH] |Immunity, Cellular [MESH] |Immunity, Humoral [MESH] |Immunity, Innate [MESH] |Immunosuppressive Agents/therapeutic use [MESH] |Islets of Langerhans Transplantation/*methods [MESH] |Kidney Transplantation/*methods [MESH]Immunological challenges and therapies in xenotransplantation (epmc).pdf DeepDyve Pubget Overpricing