Immunological Functions of the Omentum
#MMPMID28579319
Meza-Perez S
; Randall TD
Trends Immunol
2017[Jul]; 38
(7
): 526-536
PMID28579319
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The omentum is a visceral adipose tissue with unique immune functions. Although
it is primarily an adipose tissue, the omentum also contains lymphoid aggregates,
called milky spots (MSs), that contribute to peritoneal immunity by collecting
antigens, particulates, and pathogens from the peritoneal cavity and, depending
on the stimuli, promoting a variety of immune responses, including inflammation,
tolerance, or even fibrosis. Reciprocal interactions between cells in the MS and
adipocytes regulate their immune and metabolic functions. Importantly, the
omentum collects metastasizing tumor cells and supports tumor growth by
immunological and metabolic mechanisms. Here we summarize our current knowledge
about the development, organization, and function of the omentum in peritoneal
immunity.
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