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Immunological Evaluation in Patients with Familial Mediterranean fever
#MMPMID29531594
Kholoussi S
; Kholoussi N
; Zaki ME
; El-Bassyouni HT
; Elnady H
; Morcos B
; Abo-Shanab A
Open Access Maced J Med Sci
2018[Feb]; 6
(2
): 310-313
PMID29531594
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OBJECTIVE: This study aimed to investigate T & B lymphocyte subsets and Natural
Killer (NK) cells patterns in children with FMF versus normal control subjects,
to estimate the immunoglobulins IgG, IgM, and IgA levels, and to scrutinize the
possible use of Neutrophil / Lymphocyte ratio (NLR) as a marker for subclinical
inflammation in FMF patients. PATIENTS AND METHODS: A group of 42 patients with
FMF attending the Genetics Clinic at National Research Centre were included in
this study. They were 13 males and 19 females; their age ranged from 2 to 17
years old. Normal healthy subjects within the same age and sex range were
included as a control group. Complete blood picture was done for all cases, and
neutrophil/ lymphocyte ratio was calculated. Flow cytometer analysis was done for
CD3, CD4, CD8, CD19 and CD16 using monoclonal antibodies. Immunoglobulins IgG,
IgA and IgM were estimated in serum using nephelometry. RESULTS: Positive
consanguinity was present in 20 patients (47.6%). Abdominal pain was the most
common manifestation followed by fever, arthritis, and red rash. CD3, CD4 and CD8
were statistically increased in patients group as compared to normal control
group, while CD16 was statistically decreased. CONCLUSION: The study suggests
that quantitative measurement of CD expressions of CD3, CD4 and CD8 as well as
NLR might be used as valuable markers for subclinical inflammation in FMF.
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