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10.1097/MED.0000000000000248 http://scihub22266oqcxt.onion/10.1097/MED.0000000000000248 C4915062!4915062 !27119751     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27119751 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27119751 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Opin+Endocrinol+Diabetes+Obes 2016 ; 23 (3 ): 242-8 Nephropedia Template TP {{tp|p=27119751 |t=2016. Immunohistochemistry of the adrenal in primary aldosteronism |pdf=|usr=}}{{27119751 }} gab.com Text Immunohistochemistry of the adrenal in primary aldosteronism JO: Curr Opin Endocrinol Diabetes Obes http://www.kidney.de/pget.php?&tw=1&pmid=27119751 #FOAvip PURPOSE OF REVIEW: Primary aldosteronism is a major cause of hypertension; aldosterone-producing adenomas (APA) cause about half of primary aldosteronism; idiopathic hyperplasia of adrenal glomerulosa cells are responsible for the rest. A surprising variety of mutations have recently been identified in ion channels and pumps in a significant number of APA. The present review addresses histological and molecular aspects of APA and the surrounding adrenal. RECENT FINDINGS: Specific antibodies against the CYP11B2 and CYP11B1 enzymes, the last enzyme in aldosterone and cortisol synthesis, respectively, allow for the first time study of the steroidogenic capabilities of cells within the APA and adjacent adrenal. Cells expressing CYP11B2 may be scattered and/or in clusters throughout the normal adrenal zona glomerulosa. APA differ widely in the number of cells expressing CYP11B2; some did not express it at all, but were surrounded by cells, some in clusters or micronodules, that expressed CYP11B2. Some APAs also comprised cells expressing both CYP11B1 and CYP17A1. In some samples, analysis of the tissue adjacent to APA detected ion channel and pump mutations heretofore associated only with APA. SUMMARY: APAs have a complex structure and expression of steroidogenic enzymes. Twit Text FOAVip Immunohistochemistry of the adrenal in primary aldosteronism ????Curr Opin Endocrinol Diabetes Obes http://www.kidney.de/pget.php?&tw=1&pmid=27119751 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27119751 #FOAvip English Wikipedia <ref>{{Cite pmid|27119751 }}</ref> Immunohistochemistry of the adrenal in primary aldosteronism #MMPMID27119751 Gomez-Sanchez CE ; Gomez-Sanchez EP Curr Opin Endocrinol Diabetes Obes 2016[Jun]; 23 (3 ): 242-8 PMID27119751 show ga PURPOSE OF REVIEW: Primary aldosteronism is a major cause of hypertension; aldosterone-producing adenomas (APA) cause about half of primary aldosteronism; idiopathic hyperplasia of adrenal glomerulosa cells are responsible for the rest. A surprising variety of mutations have recently been identified in ion channels and pumps in a significant number of APA. The present review addresses histological and molecular aspects of APA and the surrounding adrenal. RECENT FINDINGS: Specific antibodies against the CYP11B2 and CYP11B1 enzymes, the last enzyme in aldosterone and cortisol synthesis, respectively, allow for the first time study of the steroidogenic capabilities of cells within the APA and adjacent adrenal. Cells expressing CYP11B2 may be scattered and/or in clusters throughout the normal adrenal zona glomerulosa. APA differ widely in the number of cells expressing CYP11B2; some did not express it at all, but were surrounded by cells, some in clusters or micronodules, that expressed CYP11B2. Some APAs also comprised cells expressing both CYP11B1 and CYP17A1. In some samples, analysis of the tissue adjacent to APA detected ion channel and pump mutations heretofore associated only with APA. SUMMARY: APAs have a complex structure and expression of steroidogenic enzymes. |Adrenal Glands/*enzymology [MESH] |Humans [MESH] |Hyperaldosteronism/*enzymology [MESH]Immunohistochemistry of the adrenal in primary aldosteronism (epmc).pdf DeepDyve Pubget Overpricing