Immunoglobulin-induced aseptic meningitis: a case report
#MMPMID30016937
Graça L
; Alves J
; Nuak J
; Sarmento A
BMC Neurol
2018[Jul]; 18
(1
): 97
PMID30016937
show ga
BACKGROUND: Immunoglobulin associated meningitis is a rare disease that mimics
infectious meningitis. This is, to our knowledge, the first case of
Immunoglobulin-associated meningitis described in a patient with Systemic Lupus
Erythematosus and hypogammaglobulinemia secondary to Rituximab. CASE
PRESENTATION: A 46-year-old female with a past medical history of Systemic Lupus
Erythematosus, presented with meningismus 36 h after first infusion of
intravenous immunoglobulin. The cerebrospinal fluid analysis showed neutrophilic
pleocytosis and hyperproteinorrachia. All microbiological tests were negative.
The patient recovered remarkably fast without sequela after just five days of
antibiotic therapy. CONCLUSION: Systemic Lupus Erythematosus is a well-documented
risk factor for aseptic meningitis associated with other drugs. Possibly, it is
also a risk factor for Immunoglobulin associated meningitis. This diagnosis,
although rare, should be considered in patients receiving Immunoglobulin since it
is a self-limited condition and treatment is supportive.
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