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2014 ; 211
(11
): 2159-68
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Immunoglobulin E plays an immunoregulatory role in lupus
#MMPMID25267791
Dema B
; Charles N
; Pellefigues C
; Ricks TK
; Suzuki R
; Jiang C
; Scheffel J
; Hasni S
; Hoffman V
; Jablonski M
; Sacré K
; Gobert D
; Papo T
; Daugas E
; Crampton S
; Bolland S
; Rivera J
J Exp Med
2014[Oct]; 211
(11
): 2159-68
PMID25267791
show ga
The (patho)physiological role of IgE in nonallergic inflammatory diseases is not
well understood. Here, we explored the effect of IgE deficiency on the
inflammatory response in Fc?RIIB-deficient mice as well as in mice carrying both
a deletion of Fc?RIIB and the chromosomal translocation of Y-linked autoimmune
acceleration (Yaa) that hastens and results in a more aggressive lupuslike
disease in these mice. The findings show that deficiency of IgE delays disease
development and severity as demonstrated by reduced autoantibody production and
amelioration of organ pathologies. This was associated with decreased numbers of
plasma cells and reduced levels of IgG2b and IgG3. Unexpectedly, the loss of IgE
also caused a striking decrease of immune cell infiltration in secondary lymphoid
organs with a marked effect on the presence of dendritic cells, monocytes,
neutrophils, and eosinophils in these organs and decreased activation of
basophils. The presence of autoreactive IgE in human systemic lupus erythematosus
subjects was also associated with increased basophil activation and enhanced
disease activity. These findings argue that IgE facilitates the amplification of
autoimmune inflammation.
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