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2017 ; 8
(ä): 454
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Immune-Mediated Repair: A Matter of Plasticity
#MMPMID28484454
Laurent P
; Jolivel V
; Manicki P
; Chiu L
; Contin-Bordes C
; Truchetet ME
; Pradeu T
Front Immunol
2017[]; 8
(ä): 454
PMID28484454
show ga
Though the immune system is generally defined as a system of defense, it is
increasingly recognized that the immune system also plays a crucial role in
tissue repair and its potential dysregulations. In this review, we explore how
distinct immune cell types are involved in tissue repair and how they interact in
a process that is tightly regulated both spatially and temporally. We insist on
the concept of immune cell plasticity which, in recent years, has proved
fundamental for the success/understanding of the repair process. Overall, the
perspective presented here suggests that the immune system plays a central role
in the physiological robustness of the organism, and that cell plasticity
contributes to the realization of this robustness.