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2013 ; 27
(3
): 495-520
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Immune thrombocytopenia
#MMPMID23714309
Kistangari G
; McCrae KR
Hematol Oncol Clin North Am
2013[Jun]; 27
(3
): 495-520
PMID23714309
show ga
Immune thrombocytopenia (ITP) is a common hematologic disorder characterized by
isolated thrombocytopenia. ITP presents as a primary or a secondary form. ITP may
affect individuals of all ages, with peaks during childhood and in the elderly,
in whom the age-specific incidence of ITP is greatest. Bleeding is the most
common clinical manifestation of ITP. The pathogenesis of ITP is complex,
involving alterations in humoral and cellular immunity. Corticosteroids remain
the most common first line therapy for ITP. This article summarizes the
classification and diagnosis of primary and secondary ITP, as well as the
pathogenesis and options for treatment.