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2017 ; 1
(ä): 54-62
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Immune engineering: from systems immunology to engineering immunity
#MMPMID29038795
Jiang N
Curr Opin Biomed Eng
2017[Mar]; 1
(ä): 54-62
PMID29038795
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The smallpox vaccine represents the earliest attempt in engineering immunity. The
recent success of chimeric antigen receptor T cells (CAR-T cells) in cancer once
again demonstrates the clinical potential of immune engineering. Inspired by this
success, diverse approaches have been used to boost various aspects of immunity:
engineering dendritic cells (DCs), natural killer (NK) cells, T cells,
antibodies, cytokines, small peptides, and others. With recent development of
various high-throughput technologies (of which engineers, especially biomedical
engineers/bioengineers contributed significantly), such as immune repertoire
sequencing, and analytical methods, a systems level of understanding immunity (or
the lack of it) beyond model animals has provided critical insights into the
human immune system. This review focuses on recent progressed made in systems
biology and the engineering of adaptive immunity.