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10.21037/sci.2017.03.04 http://scihub22266oqcxt.onion/10.21037/sci.2017.03.04 C5420526!5420526 !28529947     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28529947 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Stem+Cell+Investig 2017 ; 4 (ä): 32 Nephropedia Template TP {{tp|p=28529947 |t=2017. Immune checkpoint blockade for hematologic malignancies: a review |pdf=|usr=}}{{28529947 }} gab.com Text Immune checkpoint blockade for hematologic malignancies: a review JO: Stem Cell Investig http://www.kidney.de/pget.php?&tw=1&pmid=28529947 #FOAvip Immune checkpoint blockade has revolutionized the treatment of cancer, with impressive responses seen in a broad variety of tumor types. Blockade of immune checkpoints and immune signaling antibodies has shown promise in multiple types of hematologic malignancies (HMs), with dramatic single agent responses for pembrolizumab and nivolumab in Hodgkin lymphoma (HL). In this review, we outline the current state of immune checkpoint blockade drug development in HMs, and discuss mechanisms of activity and resistance, and highlight potential targets in the immune tumor microenvironment (TME). Blockade of T-cell checkpoint molecules PD-1/PD-L1 and CTLA-4 are the most clinically mature of the immune checkpoint strategies. Novel and upcoming strategies for immune checkpoint blockade drug development in HMs using innovative combinations to modulate immunologic targets shows significant promise as a way to expand the number of patients with blood cancers who could benefit from immunotherapy. Twit Text FOAVip Immune checkpoint blockade for hematologic malignancies: a review ????Stem Cell Investig http://www.kidney.de/pget.php?&tw=1&pmid=28529947 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28529947 #FOAvip English Wikipedia <ref>{{Cite pmid|28529947 }}</ref> Immune checkpoint blockade for hematologic malignancies: a review #MMPMID28529947 Pianko MJ ; Liu Y ; Bagchi S ; Lesokhin AM Stem Cell Investig 2017[]; 4 (ä): 32 PMID28529947 show ga Immune checkpoint blockade has revolutionized the treatment of cancer, with impressive responses seen in a broad variety of tumor types. Blockade of immune checkpoints and immune signaling antibodies has shown promise in multiple types of hematologic malignancies (HMs), with dramatic single agent responses for pembrolizumab and nivolumab in Hodgkin lymphoma (HL). In this review, we outline the current state of immune checkpoint blockade drug development in HMs, and discuss mechanisms of activity and resistance, and highlight potential targets in the immune tumor microenvironment (TME). Blockade of T-cell checkpoint molecules PD-1/PD-L1 and CTLA-4 are the most clinically mature of the immune checkpoint strategies. Novel and upcoming strategies for immune checkpoint blockade drug development in HMs using innovative combinations to modulate immunologic targets shows significant promise as a way to expand the number of patients with blood cancers who could benefit from immunotherapy. äImmune checkpoint blockade for hematologic malignancies: a review (epmc).pdf DeepDyve Pubget Overpricing