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10.1089/jir.2016.0086 http://scihub22266oqcxt.onion/10.1089/jir.2016.0086 C5439420!5439420 !28475463     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28475463 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Interferon+Cytokine+Res 2017 ; 37 (5 ): 198-206 Nephropedia Template TP {{tp|p=28475463 |t=2017. Immune Diseases Associated with TREX1 and STING Dysfunction |pdf=|usr=}}{{28475463 }} gab.com Text Immune Diseases Associated with TREX1 and STING Dysfunction JO: J Interferon Cytokine Res http://www.kidney.de/pget.php?&tw=1&pmid=28475463 #FOAvip The innate immune system is the first line of defense against invading pathogens. One important feature of innate immune recognition is self versus nonself discrimination. The selectivity for microbial ligands is achieved through substrate motif specificity, spatial compartmentalization, and functions of negative regulators. Loss-of-function mutations in negative regulators or gain-of-function mutations in drivers of innate immune signaling have been associated with autoimmune diseases such as lupus, rheumatoid arthritis, inflammatory vasculopathy, and a variety of interferonopathies. This review will focus on TREX1 and STING, which are opposing regulators of the cytosolic DNA-sensing pathway. Tremendous effort over the past decade among academic and clinical research groups has elucidated molecular mechanisms underlying immune diseases associated with TREX1 and STING dysfunction. We have also witnessed rapid therapeutic translation of the molecular findings. Several targeted treatment options or druggable candidates are now available for these once incurable diseases. With great enthusiasm from both academia and industry partners, we look forward to seeing the remaining scientific questions answered and, more importantly, the affected patients benefited from these discoveries. Twit Text FOAVip Immune Diseases Associated with TREX1 and STING Dysfunction ????J Interferon Cytokine Res http://www.kidney.de/pget.php?&tw=1&pmid=28475463 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28475463 #FOAvip English Wikipedia <ref>{{Cite pmid|28475463 }}</ref> Immune Diseases Associated with TREX1 and STING Dysfunction #MMPMID28475463 Yan N J Interferon Cytokine Res 2017[May]; 37 (5 ): 198-206 PMID28475463 show ga The innate immune system is the first line of defense against invading pathogens. One important feature of innate immune recognition is self versus nonself discrimination. The selectivity for microbial ligands is achieved through substrate motif specificity, spatial compartmentalization, and functions of negative regulators. Loss-of-function mutations in negative regulators or gain-of-function mutations in drivers of innate immune signaling have been associated with autoimmune diseases such as lupus, rheumatoid arthritis, inflammatory vasculopathy, and a variety of interferonopathies. This review will focus on TREX1 and STING, which are opposing regulators of the cytosolic DNA-sensing pathway. Tremendous effort over the past decade among academic and clinical research groups has elucidated molecular mechanisms underlying immune diseases associated with TREX1 and STING dysfunction. We have also witnessed rapid therapeutic translation of the molecular findings. Several targeted treatment options or druggable candidates are now available for these once incurable diseases. With great enthusiasm from both academia and industry partners, we look forward to seeing the remaining scientific questions answered and, more importantly, the affected patients benefited from these discoveries. |Exodeoxyribonucleases/*metabolism [MESH] |Humans [MESH] |Immune System Diseases/*metabolism/*physiopathology [MESH] |Membrane Proteins/*metabolism [MESH]Immune Diseases Associated with TREX1 and STING Dysfunction (epmc).pdf DeepDyve Pubget Overpricing