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2017 ; 8
(15
): 2915-2923
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Immune Cell Population in Ovarian Tumor Microenvironment
#MMPMID28928882
Cai DL
; Jin LP
J Cancer
2017[]; 8
(15
): 2915-2923
PMID28928882
show ga
Ovarian cancer, the third most common with highest mortality rates gynecological
malignancy among women in China, is characterized by a unique tumor immune
microenvironment. Immune-cell population infiltrated into the tumor tissue among
patients with ovarian cancer are associated positively or negatively with
antitumor activity. The imbalance between immune activation and immune
suppression can result in oncogenesis and cancer progression. Therefore, intense
investigation of the immunologic mechanism of ovarian cancer is urgently needed,
and a comprehensive understanding of the network in which immune cells interact
with the microenvironment, tumor cells and each other will greatly promote the
development of more effective immunotherapies for ovarian cancer. In this review,
we will focus on the main immune-cell population in ovarian tumor
microenvironment, discuss their role in tumor progression and try to give the
readers a new perspective in finding more promising therapeutic targets for
cancers.