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2018 ; 9
(ä): 1435
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Immune Cell Dynamics Unfolded by Single-Cell Technologies
#MMPMID29997618
Kunz DJ
; Gomes T
; James KR
Front Immunol
2018[]; 9
(ä): 1435
PMID29997618
show ga
The single-cell revolution is paving the way towards the molecular
characterisation of every cell type in the human body, revealing relationships
between cell types and states at high resolution. Changes in cellular phenotypes
are particularly prevalent in the immune system and can be observed in its
continuous remodelling up to adulthood, response to disease and development of
immunological memory. In this review, we delve into the world of cellular
dynamics of the immune system. We discuss current single-cell experimental and
computational approaches in this area, giving insights into plasticity and
commitment of cell fates. Finally, we provide an outlook on upcoming
technological developments and predict how these will improve our understanding
of the immune system.