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10.1016/j.addr.2016.01.008 http://scihub22266oqcxt.onion/10.1016/j.addr.2016.01.008 C5226392!5226392 !26805788     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26805788 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26805788 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Drug+Deliv+Rev 2016 ; 104 (ä): 44-60 Nephropedia Template TP {{tp|p=26805788 |t=2016. Imaging-guided delivery of RNAi for anticancer treatment |pdf=|usr=}}{{26805788 }} gab.com Text Imaging-guided delivery of RNAi for anticancer treatment JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=26805788 #FOAvip The RNA interference (RNAi) technique is a new modality for cancer therapy, and several candidates are being tested clinically. In the development of RNAi-based therapeutics, imaging methods can provide a visible and quantitative way to investigate the therapeutic effect at anatomical, cellular, and molecular level; to noninvasively trace the distribution; to and study the biological processes in preclinical and clinical stages. Their abilities are important not only for therapeutic optimization and evaluation but also for shortening of the time of drug development to market. Typically, imaging-functionalized RNAi therapeutics delivery that combines nanovehicles and imaging techniques to study and improve their biodistribution and accumulation in tumor site has been progressively integrated into anticancer drug discovery and development processes. This review presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. Finally, we focus on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. Twit Text FOAVip Imaging-guided delivery of RNAi for anticancer treatment ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=26805788 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26805788 #FOAvip English Wikipedia <ref>{{Cite pmid|26805788 }}</ref> Imaging-guided delivery of RNAi for anticancer treatment #MMPMID26805788 Wang J ; Mi P ; Lin G ; Wáng YX ; Liu G ; Chen X Adv Drug Deliv Rev 2016[Sep]; 104 (ä): 44-60 PMID26805788 show ga The RNA interference (RNAi) technique is a new modality for cancer therapy, and several candidates are being tested clinically. In the development of RNAi-based therapeutics, imaging methods can provide a visible and quantitative way to investigate the therapeutic effect at anatomical, cellular, and molecular level; to noninvasively trace the distribution; to and study the biological processes in preclinical and clinical stages. Their abilities are important not only for therapeutic optimization and evaluation but also for shortening of the time of drug development to market. Typically, imaging-functionalized RNAi therapeutics delivery that combines nanovehicles and imaging techniques to study and improve their biodistribution and accumulation in tumor site has been progressively integrated into anticancer drug discovery and development processes. This review presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. Finally, we focus on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. |*Genetic Therapy [MESH] |*RNA Interference [MESH] |Drug Delivery Systems [MESH] |Humans [MESH] |Neoplasms/genetics/*therapy [MESH] |RNA, Small Interfering/administration & dosage/therapeutic use [MESH]Imaging-guided delivery of RNAi for anticancer treatment (epmc).pdf DeepDyve Pubget Overpricing