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2016 ; 30
(2
): 88-91
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Imaging drusens using Spectral Domain Optical Coherence Tomography
#MMPMID27330382
Gella L
; Raman R
; Sharma T
Saudi J Ophthalmol
2016[Apr]; 30
(2
): 88-91
PMID27330382
show ga
PURPOSE: The purpose was to evaluate pathological changes of photoreceptor layer
and retinal pigment epithelium in eyes with drusens using Spectral Domain Optical
Coherence Tomography (SD-OCT). METHODS: Twenty-nine eyes of 29 patients with
(drusens) dry age-related macular degeneration and 43 eyes of 43 controls were
included in this study. All subjects underwent complete ophthalmic examination
including SD-OCT. Central foveal thickness (CFT), photoreceptor layer (PRL)
thickness and retinal pigment epithelial (RPE) thickness were measured and
compared between the groups. P value < 0.05 was considered statistically
significant. RESULTS: Best corrected visual acuity (BCVA) ranged between 20/20
and 20/200. RPE (36.10 ± 5.48 ?m Vs 39.27 ± 4.30) and PRL thickness
(53.93 ± 7.36 ?m Vs 61.20 ± 4.50 ?m) were significantly reduced in patients with
drusens compared to controls. Increase in age was a significant risk factor for
drusens (OR: 1.22, p < 0.001) and increased PRL thickness was a protective factor
(OR: 0.720, p = 0.002). PRL thickness was significantly associated with BCVA
(p = 0.019). CONCLUSION: With an increased resolution of SD-OCT, the involvement
of the outer retinal layers was more clearly defined. SD-OCT may allow for the
early detection of exudative changes.