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2018 ; 14
(7
): e1007046
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Illuminating pathogen-host intimacy through optogenetics
#MMPMID30001435
Arroyo-Olarte RD
; Thurow L
; Kozjak-Pavlovic V
; Gupta N
PLoS Pathog
2018[Jul]; 14
(7
): e1007046
PMID30001435
show ga
The birth and subsequent evolution of optogenetics has resulted in an
unprecedented advancement in our understanding of the brain. Its outstanding
success does usher wider applications; however, the tool remains still largely
relegated to neuroscience. Here, we introduce selected aspects of optogenetics
with potential applications in infection biology that will not only answer
long-standing questions about intracellular pathogens (parasites, bacteria,
viruses) but also broaden the dimension of current research in entwined models.
In this essay, we illustrate how a judicious integration of optogenetics with
routine methods can illuminate the host-pathogen interactions in a way that has
not been feasible otherwise.