Saudi J Ophthalmol
2015[Jan]; 29
(1
): 53-6
PMID25859140
show ga
IgG4-related disease is a fibro-inflammatory condition with tendency to form
tumors with inflammatory infiltrate with IgG4 rich plasma cells and elevation of
IgG4 level in serum, which may affect virtually every organ and tissue in the
organism. IgG4-related ophthalmic disease may present as dacryoadenitis,
myositis, other orbital tissues, hypophysitis or pachymeningitis causing cranial
neuropathies. The diagnosis of IgG4-related disease is based on a typical
clinical scenario, supportive laboratory data, expected radiological
characteristics and distinct histopathological and immunohistochemical features.
Corticosteroid followed by the use of long-term immunosuppressive therapy is the
most commonly attempted treatment.
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