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10.1155/2017/5348928

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suck abstract from ncbi


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pmid28884026
      J+Obes 2017 ; 2017 (ä): 5348928
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  • Idiopathic Intracranial Hypertension: Prognostic Factors and Multidisciplinary Management #MMPMID28884026
  • Chagot C ; Blonski M ; Machu JL ; Bracard S ; Lacour JC ; Richard S
  • J Obes 2017[]; 2017 (ä): 5348928 PMID28884026 show ga
  • BACKGROUND: Idiopathic intracranial hypertension (IIH) mostly affects young obese women and can lead to permanent visual impairment. However, prognostic factors and therapeutic strategy remain unclear. METHODS: We retrospectively collected data from all patients diagnosed and managed for IIH in our university center from January 2001 to December 2016. RESULTS: Seventy-nine patients were diagnosed with IIH. Bilateral transverse sinus stenosis (TSS) was found in 74% of the population. Visual outcome at 6 months was poor for 46% of patients, including all patients presenting weight gain of at least 5% since diagnosis (p < 0.001), whereas mean body mass index at diagnosis was not different between patients with poor versus good outcome (32.9 ± 7.7 versus 34.6 ± 9.4?kg·m(-2)). Other significant factors of poor prognosis were bilateral TSS (OR = 5.2; 95 CI: 1.24-24.9; p = 0.024). Thirteen patients with poor outcome after 6-month assessment underwent unilateral TSS stenting leading to visual improvement in 11 cases. CONCLUSION: Weight gain, rather than initial weight, emerged as the leading factor of poor visual outcome in patients with IIH, followed by presence of bilateral TSS. Consequently, first-line treatment must include dietary measures to control weight. Unilateral stenting appears to be a safe second-line treatment option for patients with bilateral TSS.
  • |*Stents [MESH]
  • |Adolescent [MESH]
  • |Adult [MESH]
  • |Constriction, Pathologic [MESH]
  • |Decision Support Techniques [MESH]
  • |Female [MESH]
  • |Humans [MESH]
  • |Magnetic Resonance Imaging [MESH]
  • |Male [MESH]
  • |Middle Aged [MESH]
  • |Obesity/*complications [MESH]
  • |Prognosis [MESH]
  • |Pseudotumor Cerebri/complications/diagnostic imaging/*surgery [MESH]
  • |Retrospective Studies [MESH]
  • |Transverse Sinuses/pathology/*surgery [MESH]
  • |Vision Disorders/*prevention & control [MESH]


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