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10.1097/MD.0000000000007741 http://scihub22266oqcxt.onion/10.1097/MD.0000000000007741 C5662349!5662349 !29049183     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29049183 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Medicine+(Baltimore) 2017 ; 96 (42 ): e7741 Nephropedia Template TP {{tp|p=29049183 |t=2017. Identifying key genes associated with acute myocardial infarction |pdf=|usr=}}{{29049183 }} gab.com Text Identifying key genes associated with acute myocardial infarction JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=29049183 #FOAvip BACKGROUND: This study aimed to identify key genes associated with acute myocardial infarction (AMI) by reanalyzing microarray data. METHODS: Three gene expression profile datasets GSE66360, GSE34198, and GSE48060 were downloaded from GEO database. After data preprocessing, genes without heterogeneity across different platforms were subjected to differential expression analysis between the AMI group and the control group using metaDE package. P?<?.05 was used as the cutoff for a differentially expressed gene (DEG). The expression data matrices of DEGs were imported in ReactomeFIViz to construct a gene functional interaction (FI) network. Then, DEGs in each module were subjected to pathway enrichment analysis using DAVID. MiRNAs and transcription factors predicted to regulate target DEGs were identified. Quantitative real-time polymerase chain reaction (RT-PCR) was applied to verify the expression of genes. RESULT: A total of 913 upregulated genes and 1060 downregulated genes were identified in the AMI group. A FI network consists of 21 modules and DEGs in 12 modules were significantly enriched in pathways. The transcription factor-miRNA-gene network contains 2 transcription factors FOXO3 and MYBL2, and 2 miRNAs hsa-miR-21-5p and hsa-miR-30c-5p. RT-PCR validations showed that expression levels of FOXO3 and MYBL2 were significantly increased in AMI, and expression levels of hsa-miR-21-5p and hsa-miR-30c-5p were obviously decreased in AMI. CONCLUSION: A total of 41 DEGs, such as SOCS3, VAPA, and COL5A2, are speculated to have roles in the pathogenesis of AMI; 2 transcription factors FOXO3 and MYBL2, and 2 miRNAs hsa-miR-21-5p and hsa-miR-30c-5p may be involved in the regulation of the expression of these DEGs. Twit Text FOAVip Identifying key genes associated with acute myocardial infarction ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=29049183 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29049183 #FOAvip English Wikipedia <ref>{{Cite pmid|29049183 }}</ref> Identifying key genes associated with acute myocardial infarction #MMPMID29049183 Cheng M ; An S ; Li J Medicine (Baltimore) 2017[Oct]; 96 (42 ): e7741 PMID29049183 show ga BACKGROUND: This study aimed to identify key genes associated with acute myocardial infarction (AMI) by reanalyzing microarray data. METHODS: Three gene expression profile datasets GSE66360, GSE34198, and GSE48060 were downloaded from GEO database. After data preprocessing, genes without heterogeneity across different platforms were subjected to differential expression analysis between the AMI group and the control group using metaDE package. P? |Cell Cycle Proteins/*genetics [MESH] |Databases, Genetic [MESH] |Down-Regulation/genetics [MESH] |Forkhead Box Protein O3/*genetics [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |Gene Regulatory Networks/*genetics [MESH] |Genetic Association Studies [MESH] |Humans [MESH] |MicroRNAs/metabolism [MESH] |Myocardial Infarction/*genetics [MESH] |Real-Time Polymerase Chain Reaction [MESH] |Trans-Activators/*genetics [MESH] |Transcription Factors/genetics [MESH]Identifying key genes associated with acute myocardial infarction (epmc).pdf DeepDyve Pubget Overpricing