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10.1126/science.aag0821 http://scihub22266oqcxt.onion/10.1126/science.aag0821 C5432043!5432043 !27609886     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27609886 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Science 2016 ; 353 (6304 ): 1123-9 Nephropedia Template TP {{tp|p=27609886 |t=2016. Identification of an elaborate complex mediating postsynaptic inhibition |pdf=|usr=}}{{27609886 }} gab.com Text Identification of an elaborate complex mediating postsynaptic inhibition JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=27609886 #FOAvip Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. The composition of the inhibitory postsynapse and the mechanistic basis of its regulation, however, remain poorly understood. We used an in vivo chemico-genetic proximity-labeling approach to discover inhibitory postsynaptic proteins. Quantitative mass spectrometry not only recapitulated known inhibitory postsynaptic proteins but also revealed a large network of new proteins, many of which are either implicated in neurodevelopmental disorders or are of unknown function. Clustered regularly interspaced short palindromic repeats (CRISPR) depletion of one of these previously uncharacterized proteins, InSyn1, led to decreased postsynaptic inhibitory sites, reduced the frequency of miniature inhibitory currents, and increased excitability in the hippocampus. Our findings uncover a rich and functionally diverse assemblage of previously unknown proteins that regulate postsynaptic inhibition and might contribute to developmental brain disorders. Twit Text FOAVip Identification of an elaborate complex mediating postsynaptic inhibition ????Science http://www.kidney.de/pget.php?&tw=1&pmid=27609886 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27609886 #FOAvip English Wikipedia <ref>{{Cite pmid|27609886 }}</ref> Identification of an elaborate complex mediating postsynaptic inhibition #MMPMID27609886 Uezu A ; Kanak DJ ; Bradshaw TW ; Soderblom EJ ; Catavero CM ; Burette AC ; Weinberg RJ ; Soderling SH Science 2016[Sep]; 353 (6304 ): 1123-9 PMID27609886 show ga Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. The composition of the inhibitory postsynapse and the mechanistic basis of its regulation, however, remain poorly understood. We used an in vivo chemico-genetic proximity-labeling approach to discover inhibitory postsynaptic proteins. Quantitative mass spectrometry not only recapitulated known inhibitory postsynaptic proteins but also revealed a large network of new proteins, many of which are either implicated in neurodevelopmental disorders or are of unknown function. Clustered regularly interspaced short palindromic repeats (CRISPR) depletion of one of these previously uncharacterized proteins, InSyn1, led to decreased postsynaptic inhibitory sites, reduced the frequency of miniature inhibitory currents, and increased excitability in the hippocampus. Our findings uncover a rich and functionally diverse assemblage of previously unknown proteins that regulate postsynaptic inhibition and might contribute to developmental brain disorders. |*Neural Inhibition [MESH] |Animals [MESH] |Brain Diseases/genetics/*metabolism [MESH] |Carrier Proteins/genetics/metabolism [MESH] |Clustered Regularly Interspaced Short Palindromic Repeats [MESH] |Hippocampus/*metabolism [MESH] |Mass Spectrometry [MESH] |Membrane Proteins/genetics/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mutation [MESH] |Nerve Tissue Proteins/genetics/*metabolism [MESH] |Post-Synaptic Density/*metabolism [MESH]Identification of an elaborate complex mediating postsynaptic inhibiti(epmc).pdf DeepDyve Pubget Overpricing